[A Case Report-Remarkable Response of mFOLFIRINOX in Recurrent Hepatic Metastasis of Intraductal Papillary Mucinous...

A 76-year-old female presented with multiple pancreatic cystic lesions, the largest measuring 10 mm in diameter, which were identified during an examination by another department at our hospital. Following referral to our department, she underwent observation because CT scans showed that the lesions tended to enlarge. Subsequent MRCP confirmed a diagnosis of a mixed-type IPMN, prompting surgical intervention. A distal pancreatectomy with D2 lymphadenectomy was performed. Pathological examination revealed IPMC(pT1cpN0M0, pStage ⅠA). Postoperatively, the patient received adjuvant S-1 therapy. In the second year after surgery, CT and MRI revealed hepatic recurrence in segments S8(12 mm)and S5 (5 mm). mFOLFIRINOX was initiated, and after 8 courses, a follow-up CT showed the complete disappearance of both lesions, achieving a complete response(CR). mFOLFIRINOX was continued for 21 courses, without recurrence, over the subsequent year. This case highlights the efficacy of mFOLFIRINOX in treating recurrent hepatic metastases of IPMC and warrants further investigation.