Effect of Natural Polyphenols on Breast Cancer Chemoprevention and Treatment

Area of Science:

• Oncology
• Pharmacology
• Natural Products Chemistry

Background:

• Breast cancer is a leading global malignancy in women, with drug resistance and metastasis posing significant challenges.
• Natural products offer a valuable source for novel small-molecule anticancer drugs due to their low toxicity and diverse structures.
• Polyphenols are recognized for their potential in breast cancer prevention and as adjuncts to conventional therapies.

Purpose of the Study:

• To review the antitumor effects of curcumin, resveratrol, and polydatin on breast cancer.
• To synthesize findings from in vitro and preclinical studies on these natural compounds.
• To highlight their mechanisms of action in combating breast cancer.

Main Methods:

• Literature search of major scientific databases.
• Inclusion of in vitro and preclinical studies with robust scientific evidence.
• Focus on studies reporting protective effects in breast cancer treatment.

Main Results:

• Curcumin, resveratrol, and polydatin demonstrate antioxidant, anti-inflammatory, and anticancer properties.
• These compounds enhance drug efficacy, reduce chemoresistance, inhibit angiogenesis, and suppress tumor growth.
• They induce apoptosis, autophagy, and cell cycle arrest via multiple molecular pathways.

Conclusions:

• Curcumin, resveratrol, and polydatin exhibit significant potential as therapeutic agents or adjuncts in breast cancer treatment.
• Their multifaceted mechanisms involve modulating key signaling pathways like NF-κB, PI3K/Akt/mTOR, and MAPK.
• Further research into these natural compounds could lead to novel strategies for overcoming breast cancer drug resistance and metastasis.