Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Metastasis02:30

Metastasis

5.5K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
5.5K
Cancer Prevention02:59

Cancer Prevention

6.0K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
6.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Single-cell transcriptomics-guided dynamic hydrogel delivery of artemisia argyi-derived EVs relieves ER stress and promotes diabetic wound regeneration.

Journal of nanobiotechnology·2026
Same author

Breaking senescence restriction: MAFK-AREG axis promotes NSCLC cells to resist doxorubicin.

Oncology letters·2026
Same author

HERALDS: a flexible, high-resolution volumetric endoscopy-design, calibration, and performance evaluation.

Optics express·2026
Same author

Exosomes derived from senescent skeletal muscle cells aggravate nucleus pulposus cell metabolic dysregulation via p38MAPK pathway for promoting intervertebral disc degeneration.

BMC musculoskeletal disorders·2026
Same author

Analysis of Autophagy-Related Gene Signature Associated With Clinical Prognosis and Immune Microenvironment in Colorectal Cancer.

Mediators of inflammation·2026
Same author

Apoptotic extracellular vesicles derived from MSCs exposed to hypoxic and inflammatory environments slow intervertebral disc degeneration by enhancing cell activity and regulating immunity microenvironment.

Materials today. Bio·2026

Related Experiment Video

Updated: May 15, 2025

Systems Biology of Metabolic Regulation by Estrogen Receptor Signaling in Breast Cancer
10:36

Systems Biology of Metabolic Regulation by Estrogen Receptor Signaling in Breast Cancer

Published on: March 17, 2016

10.3K

Causal associations between blood metabolites and breast cancer.

Guanying Liang1, Dazhuang Miao2, Chun Du1

  • 1Department of Pathology, Affiliated Cancer Hospital of Harbin Medical University, Nangang, Harbin, Heilongjiang, China.

Archives of Medical Science : AMS
|April 7, 2025
PubMed
Summary

This study identified five blood metabolites, including serine and X-12696, as potential biomarkers for breast cancer risk. These findings advance our understanding of metabolomics in cancer development.

Keywords:
Mendelian randomizationbreast cancermetabolites

More Related Videos

Generation of Organ-conditioned Media and Applications for Studying Organ-specific Influences on Breast Cancer Metastatic Behavior
09:44

Generation of Organ-conditioned Media and Applications for Studying Organ-specific Influences on Breast Cancer Metastatic Behavior

Published on: June 13, 2016

8.4K
A Portal Vein Injection Model to Study Liver Metastasis of Breast Cancer
07:35

A Portal Vein Injection Model to Study Liver Metastasis of Breast Cancer

Published on: December 26, 2016

40.4K

Related Experiment Videos

Last Updated: May 15, 2025

Systems Biology of Metabolic Regulation by Estrogen Receptor Signaling in Breast Cancer
10:36

Systems Biology of Metabolic Regulation by Estrogen Receptor Signaling in Breast Cancer

Published on: March 17, 2016

10.3K
Generation of Organ-conditioned Media and Applications for Studying Organ-specific Influences on Breast Cancer Metastatic Behavior
09:44

Generation of Organ-conditioned Media and Applications for Studying Organ-specific Influences on Breast Cancer Metastatic Behavior

Published on: June 13, 2016

8.4K
A Portal Vein Injection Model to Study Liver Metastasis of Breast Cancer
07:35

A Portal Vein Injection Model to Study Liver Metastasis of Breast Cancer

Published on: December 26, 2016

40.4K

Area of Science:

  • Metabolomics
  • Genetics
  • Oncology

Background:

  • The relationship between blood metabolites and breast cancer risk is not well understood.
  • Identifying reliable biomarkers is crucial for early detection and prevention strategies.

Purpose of the Study:

  • To systematically identify key human blood metabolites associated with breast cancer development using a Mendelian randomization approach.
  • To evaluate the potential of these metabolites as biomarkers for breast cancer risk.

Main Methods:

  • A two-sample Mendelian randomization (MR) analysis was performed.
  • Data were sourced from large-scale genome-wide association study (GWAS) databases.
  • Instrumental variables from 453 metabolic profiles and breast cancer data from over 378,000 individuals were utilized.

Main Results:

  • Five blood metabolites were identified as potential breast cancer biomarkers: serine, 10-undecenoate (11:1n1), X-12696, X-14626, and succinyl carnitine.
  • Serine and X-12696 exhibited the strongest associations with increased breast cancer risk.
  • Sensitivity analyses confirmed the robustness of findings and absence of pleiotropy.

Conclusions:

  • Serine, 10-undecenoate (11:1n1), X-12696, X-14626, and succinylcarnitine are identified as potential blood biomarkers for breast cancer.
  • This research contributes novel insights into metabolomic profiles and their link to breast cancer.
  • Further validation is warranted to confirm their clinical utility in assessing breast cancer risk.