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Lung Capacity

Lung Capacity

The air in the lungs is measured in volumes and capacities. Lung volume measures reflect the amount of air taken in, released, or left over after a lung function, like a single inhalation. Lung capacity measures are sums of two or more lung volume measures.

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Related Experiment Video

Updated: May 15, 2025

Incorporation of a Survivable Liver Biopsy Procedure in Mice to Assess Non-alcoholic Steatohepatitis NASH Resolution

Incorporation of a Survivable Liver Biopsy Procedure in Mice to Assess Non-alcoholic Steatohepatitis NASH Resolution

Published on: April 16, 2019

Lung function and nonalcoholic fatty liver disease: a Mendelian randomization study.

Jiran Shen¹, Yue Wang², Sijing Zhou³

¹Department of Respiratory and Critical Care Medicine, the First Affiliated Hospital of Anhui Medical University, Hefei, China.

Archives of Medical Science : AMS

|April 7, 2025

Summary

Reduced lung function, specifically forced expiratory volume in 1 second (FEV1), is causally linked to a higher risk of non-alcoholic fatty liver disease (NAFLD). This finding suggests FEV1 may aid in NAFLD risk assessment and prevention strategies.

Keywords:

Mendelian randomization forced expiratory volume in 1 s (FEV1)forced vital capacity (FVC)lung function nonalcoholic fatty liver disease

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Area of Science:

Pulmonology
Hepatology
Genetics

Background:

Observational studies suggest links between pulmonary function (FEV1, FVC) and non-alcoholic fatty liver disease (NAFLD).
Observational data are limited by bias and reverse causality, hindering causal inference.

Purpose of the Study:

To investigate the causal effect of pulmonary function on NAFLD risk.
To employ Mendelian randomization (MR) to establish causality.

Main Methods:

Univariate, multivariate, and bidirectional two-sample MR analyses were conducted.
Inverse variance weighting was the primary analysis method, supplemented by complementary methods.
Sensitivity analyses were performed to assess pleiotropy.

Main Results:

Increased FEV1 and FVC showed associations with decreased NAFLD risk.
After adjusting for height, only FEV1 maintained a significant association with reduced NAFLD risk.
No significant causal effect of NAFLD on lung function was detected in reverse MR analysis.

Conclusions:

Reduced lung function, particularly FEV1, is causally associated with increased NAFLD risk.
FEV1 may serve as a valuable marker for NAFLD risk assessment.
Targeting FEV1 could be a potential strategy for NAFLD prevention.