Oncogenic human papillomavirus infection (HPV 16/18) and associated factors among women in East Gojjam Zone, NorthWest Ethiopia 2021
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View abstract on PubMed
Summary
This summary is machine-generated.This study found that 14.2% of Ethiopian women had oncogenic human papillomavirus (HPV) 16/18 infection. Key risk factors included older age, early sexual activity, sexually transmitted infections, HIV positivity, and multiple sexual partners.
Area Of Science
- Oncology
- Virology
- Epidemiology
Background
- Human papillomavirus (HPV) is a common sexually transmitted pathogen causing cervical cancer.
- Two oncogenic HPV types, 16 and 18, are responsible for a significant proportion of HPV-related cancers.
- Limited data exists on HPV 16/18 prevalence and associated factors in Ethiopia.
Purpose Of The Study
- To determine the prevalence of oncogenic HPV 16/18 infection among women in Ethiopia.
- To identify factors associated with HPV 16/18 infection in this population.
Main Methods
- An institutional-based cross-sectional study involving 337 women screened for cervical cancer.
- Data collected via questionnaire and HPV 16/18 specific testing (OncoE6TM Cervical Test) on cervical swabs.
- Descriptive and multivariate logistic regression analyses were used to determine prevalence and associated factors.
Main Results
- The prevalence of HPV 16/18 infection was 14.2% (95% CI: 10.7%-18.1%).
- Significant associated factors included older age (55-65 years), early sexual initiation, history of sexually transmitted infections (STI), HIV positive status, and a higher number of lifetime sexual partners.
- Specifically, age group 55-65 (AOR=7.91), early sexual initiation (AOR=5.36), STI history (AOR=3.52), HIV positive status (AOR=6.8), and multiple partners (AOR=4.37) were independently associated with HPV 16/18 infection.
Conclusions
- A notable prevalence of oncogenic HPV 16/18 infection was observed in Ethiopian women.
- Older age, early sexual debut, STI history, HIV status, and multiple sexual partners are significant risk factors.
- Targeted screening and HPV vaccination for high-risk women are recommended, alongside further research on cervical lesions.
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