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Lymphocytic thyroiditis with an oncocytic alteration in a laboratory beagle
Osamu Hashiguchi1, Kohji Tanaka2, Yuko Yamaguchi1
1Pathology Division, Gotemba Laboratory, BoZo Research Center Inc., 1284 Kamado, Gotemba, Shizuoka 412-0039, Japan.
Journal of Toxicologic Pathology
|April 7, 2025
Summary
This study describes lymphocytic thyroiditis in a beagle, revealing distinct cell types similar to human Hashimoto thyroiditis. The findings highlight oncocytic alterations in canine thyroid cells.
Area of Science:
- Veterinary Pathology
- Endocrinology
Background:
- Lymphocytic thyroiditis is an autoimmune condition affecting the thyroid gland.
- Understanding its characteristics in animals is crucial for comparative pathology.
Observation:
- A four-year-old male beagle presented with lymphocytic thyroiditis.
- Histopathology revealed two distinct cell types (Type A and Type B) infiltrating the thyroid.
- Immunohistochemistry and ultrastructural analysis provided insights into cell origins and characteristics.
Findings:
- Type A cells, resembling oncocytic oxyphils, were positive for thyroglobulin, suggesting follicular cell origin.
- Type B cells were positive for calcitonin and synaptophysin, indicating C-cell origin.
- The observed thyroiditis showed morphological similarities to human Hashimoto thyroiditis, notably oncocytic changes.
Implications:
- This case contributes to the understanding of canine thyroid pathology.
- The findings support the use of canine models for studying human thyroid diseases.
- Further research can explore the specific mechanisms and genetic factors involved in canine lymphocytic thyroiditis.
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