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Microfluidic synthesis of stable and uniform curcumin-loaded solid lipid nanoparticles with high encapsulation
Seon Tae Kim1, Hee Moon Lee1, Jae Hwan Jung1
1Intergrative Drug Delivery & Diagnosis Laboratory, Department of Pharmaceutical Engineering, Dankook University 119 Dandae-ro, Dongnam-gu, Cheonan-si Cheonan Chungcheongnam-do 31116 Republic of Korea.
RSC Advances
|April 7, 2025
Summary
Microfluidic machines enhance Solid Lipid Nanoparticle (SLN) production for poorly soluble curcumin, improving reproducibility and stability. This method achieves over 60% encapsulation efficiency and sustained release for six days.
Area of Science:
- Nanotechnology
- Materials Science
- Pharmaceutical Sciences
Background:
- Solid Lipid Nanoparticles (SLNs) are effective for encapsulating poorly soluble drugs like curcumin.
- Traditional bulk methods for SLN synthesis suffer from low reproducibility and encapsulation efficiency.
- Curcumin's poor solubility limits its therapeutic applications, necessitating advanced delivery systems.
Purpose of the Study:
- To develop a more reproducible and efficient method for synthesizing Solid Lipid Nanoparticles (SLNs) for curcumin encapsulation.
- To improve encapsulation efficiency and colloidal stability of curcumin-loaded SLNs.
- To enable large-scale production of stable SLNs using microfluidic technology.
Main Methods:
- Utilized a microfluidic machine equipped with a temperature controller for SLN synthesis.
- Employed microfluidic mixing to achieve uniform dispersion of curcumin in solid lipids.
- Evaluated encapsulation efficiency, drug release profile, and colloidal stability of the synthesized SLNs.
Main Results:
- Achieved an encapsulation efficiency exceeding 60% for curcumin-loaded SLNs.
- Synthesized SLNs demonstrated sustained drug release over approximately six days.
- The SLNs exhibited excellent colloidal stability, remaining non-aggregated for two weeks.
Conclusions:
- Microfluidic synthesis offers superior reproducibility and stability for SLN production compared to bulk methods.
- The temperature-controlled microfluidic approach facilitates scalable and efficient production of high-quality SLNs.
- Enhanced SLNs hold promise for improving the delivery and efficacy of poorly soluble compounds like curcumin.
