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Updated: May 15, 2025

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Targeted Therapy Evolution from Defining a Sub-population to Crossing Multi-indications

Daohong Chen1

  • 1Research Institute, Changshan Biochemical Pharmaceutical, North Head of Yinchuan Street, Zhengding New District, Shijiazhuang, Hebei, China, 050800.

Advanced Pharmaceutical Bulletin
|April 7, 2025
PubMed
Abstract

Insights

This review highlights a new disease classification based on shared molecular pathways, improving drug development. Repurposing drugs and tissue-agnostic approvals offer safer, more affordable pharmaceutical innovation.

Area of Science:

  • Molecular biology
  • Pathogenesis
  • Pharmacology

Background:

  • Emerging disease classification framework based on shared molecular pathogenesis across diverse organs and tissues.
  • Review of targeted medications and their expanding clinical indications in oncology and beyond.

Discussion:

  • Explores a novel classification framework for diseases based on underlying molecular pathogenesis.
  • Discusses the potential for pharmaceutical innovation through a broader medical perspective.

Key Insights:

  • An updated profile of targeted medications with extended clinical indications in oncology and other fields.
  • Pharmaceutic development can be made less risky and more affordable.

Outlook:

  • Drug repurposing and tissue-agnostic approvals can streamline pharmaceutical development.
  • Inspires more efficient paradigms for pharmaceutical innovation.
Keywords:
Drug repurposeTargeted therapyTissue agnostic approval

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