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Glucagon-like Receptor Agonists

Glucagon-like Receptor Agonists

Incretins include glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), which stimulate insulin secretion post-meals. In type 2 diabetes, GIP's efficacy is reduced, making GLP-1 a viable drug target. GIP originates from preproGIP.
GLP-1, when administered in high doses intravenously, triggers insulin secretion, inhibits glucagon release, slows gastric emptying, reduces food intake, and restores normal insulin secretion. However, its rapid inactivation by...

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Updated: May 15, 2025

A Chronic High-Intensity Interval Training and Diet-Induced Obesity Model to Maximize Exercise Effort and Induce Physiologic Changes in Rats

A Chronic High-Intensity Interval Training and Diet-Induced Obesity Model to Maximize Exercise Effort and Induce Physiologic Changes in Rats

Published on: April 28, 2023

Comparative Effects of Exercise and GLP-1 RAs on Type 2 Diabetic Rat Model: A Systematic Review.

Sumera Afzal¹, Hira Attique², Abdul Hameed³

¹Senior Lecturer, Ziauddin College of Physical Therapy, Faculty of Allied Health Sciences, Ziauddin University, Karachi, Pakistan.

International Journal of Exercise Science

|April 7, 2025

Summary

Exercise and GLP-1 receptor agonists show promise for managing type 2 diabetes (T2D) in rat models. These interventions improve glucose control, insulin sensitivity, and overall metabolic health, offering potential new therapeutic avenues.

Keywords:

Exercise Type 2 diabetes diabetes complications glucose insulin

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Last Updated: May 15, 2025

A Chronic High-Intensity Interval Training and Diet-Induced Obesity Model to Maximize Exercise Effort and Induce Physiologic Changes in Rats

A Chronic High-Intensity Interval Training and Diet-Induced Obesity Model to Maximize Exercise Effort and Induce Physiologic Changes in Rats

Published on: April 28, 2023

Author Spotlight: Exploring the Impact of Reduced Resistance Exercise Volume on Metabolic Health

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Published on: December 1, 2023

Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model

Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model

Published on: November 29, 2024

Area of Science:

Endocrinology
Metabolic Diseases
Pharmacology

Background:

Type 2 diabetes (T2D) is a global health crisis with severe complications like cardiovascular disease (CVD), nephropathy, neuropathy, and retinopathy.
Current T2D treatments focus on glycemic control and insulin sensitivity, but non-traditional approaches are gaining attention.

Purpose of the Study:

To systematically review and compare the effectiveness of exercise and glucagon-like peptide-1 receptor agonists (GLP-1RAs) in managing T2D.
To evaluate their impact on pancreatic beta-cell function, insulin secretion, glucose levels, and insulin resistance in T2D models.

Main Methods:

A systematic review of studies published from inception to 2024 was conducted across seven electronic databases.
13 studies involving male Wistar, male Sprague Dawley, and adult female Wistar albino rats (200-250g) met inclusion criteria, examining exercise and GLP-1RAs in diabetic and non-diabetic rats.

Main Results:

Synthesized findings indicate that both exercise and GLP-1RAs exert beneficial effects on glucose control and insulin sensitivity in diabetic rat models.
These interventions positively impact metabolic health, suggesting a therapeutic potential for T2D management.

Conclusions:

Exercise and GLP-1RAs demonstrate a promising therapeutic effect in managing T2D and its associated metabolic dysfunctions in preclinical models.
Further research is warranted to fully elucidate the underlying cellular and molecular mechanisms driving these benefits and their clinical applicability.