Comparative Effects of Exercise and GLP-1 RAs on Type 2 Diabetic Rat Model: A Systematic Review

Type 2 diabetes mellitus (T2D) is a major health problem worldwide having life-threatening complications causing mortality and a rise in prevalence. Effective treatment strategies are vital for managing diabetes and its associated complications including cardiovascular disease (CVD), nephropathy, neuropathy, and retinopathy. This systematic review aims to evaluate effective treatment approaches, focusing on the comparative effects of exercise and GLP-1 receptor agonists (GLP-1RAs) in T2D rat models. Current pharmacological therapies primarily target glycemic control and insulin sensitivity. However, there is a growing concern in non-traditional approaches that involve exercise and GLP-1 RAs for managing T2D. These therapies are crucial as they have the potential to improve pancreatic β-cell efficiency to secrete insulin, control blood glucose levels, decrease insulin resistance, and manage diabetes-related issues. Studies were searched in seven electronic databases including Google Scholar, MEDLINE, PubMed, Cochrane Library, Scopus, PEDro, and Web of Science from inception till 2024. Out of 16,500 documents retrieved between 2020 and 2024, 58 full-text articles were assessed in detail, and 13 studies met the inclusion criteria that include Male Wistar, Male Sprague Dawley and Adult female Wistar albino rats weighing 200-250 grams. These experimental studies examined the effects of exercise and different GLP-1 RAs on 103 diabetics and 103 non-diabetic rats. Overall, synthesized findings revealed a promising effect on glucose control, insulin sensitivity, and metabolic health in diabetic rats. Further research is needed to elucidate the cellular and molecular mechanism(s) through which exercise and GLP-1 RAs manage T2D and its associated complications including cardiovascular disease (CVD), nephropathy, neuropathy, and retinopathy.