Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Chronic Pancreatitis II: Collaborative Care

Chronic Pancreatitis II: Collaborative Care

The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Elevations in Donor-Derived Cell-Free DNA and Allograft Outcomes in Kidney Transplantation.

Journal of the American Society of Nephrology : JASN·2026

Same author

Rapidly Recurrent Retroperitoneal Cystic Lesion With Mass Effect in a Kidney Transplant Recipient: A Diagnostic and Management Challenge.

Cureus·2026

Same author

Correlating Prematriculation Metrics With Preclerkship and Board Examination Performance: A Systematic Review and Meta-Analysis of Outcomes.

Medical science educator·2026

Same author

Racial Variation of Donor-Derived Cell-Free DNA in Kidney Transplant Recipients.

Progress in transplantation (Aliso Viejo, Calif.)·2025

Same author

Transitional Cell Carcinoma Arising From the Renal Allograft: A Case Series and Review of the Literature.

Cureus·2024

Same author

High Intrapatient Tacrolimus Variability and Increased Cell-Free DNA in Kidney Transplant Recipients.

Progress in transplantation (Aliso Viejo, Calif.)·2024

Search research articles

Related Experiment Video

Updated: May 15, 2025

Surgical Tips and Tricks for Performing Porcine Pancreas Transplantation

Surgical Tips and Tricks for Performing Porcine Pancreas Transplantation

Published on: July 20, 2022

C-peptide Trajectory Following Pancreas Transplantation.

Jordan A Williamson¹, Kayla J Dobies¹, Abraham M Velazquez¹

¹Surgery, Rush University Medical Center, Chicago, USA.

|April 7, 2025

Summary

This summary is machine-generated.

Pancreas transplant recipients with high pre-transplant C-peptide levels showed unexpected C-peptide level declines post-transplant. These findings challenge the predictive value of pre-transplant C-peptide for pancreas transplant success.

Keywords:

c-peptide glomerular filtration rate pancreas transplantation patient outcome assessment type 2 diabetes mellitus

More Related Videos

Mouse Model for Pancreas Transplantation Using a Modified Cuff Technique

Mouse Model for Pancreas Transplantation Using a Modified Cuff Technique

Published on: December 16, 2017

Longitudinal In Vivo Imaging and Quantification of Human Pancreatic Islet Grafting and Contributing Host Cells in the Anterior Eye Chamber

Longitudinal In Vivo Imaging and Quantification of Human Pancreatic Islet Grafting and Contributing Host Cells in the Anterior Eye Chamber

Published on: June 11, 2020

Related Experiment Videos

Last Updated: May 15, 2025

Surgical Tips and Tricks for Performing Porcine Pancreas Transplantation

Surgical Tips and Tricks for Performing Porcine Pancreas Transplantation

Published on: July 20, 2022

Mouse Model for Pancreas Transplantation Using a Modified Cuff Technique

Mouse Model for Pancreas Transplantation Using a Modified Cuff Technique

Published on: December 16, 2017

Longitudinal In Vivo Imaging and Quantification of Human Pancreatic Islet Grafting and Contributing Host Cells in the Anterior Eye Chamber

Longitudinal In Vivo Imaging and Quantification of Human Pancreatic Islet Grafting and Contributing Host Cells in the Anterior Eye Chamber

Published on: June 11, 2020

Area of Science:

Nephrology
Endocrinology
Transplantation Medicine

Background:

Pancreas transplantation offers reliable glycemic control for insulin-dependent diabetes mellitus.
Standardized recipient selection criteria are lacking, impacting transplant outcomes.
The role of pre-transplant C-peptide levels in predicting post-transplant success remains unclear.

Purpose of the Study:

To investigate post-transplant C-peptide trends in recipients with varying pre-transplant C-peptide levels.
To determine the impact of pre-transplant C-peptide levels on patient and graft survival after pancreas transplantation.
To clarify the correlation between pre-transplant C-peptide and post-transplant outcomes.

Main Methods:

Retrospective review of 78 pancreas transplant recipients (2012-2022).
Categorization based on pre-transplant C-peptide levels: elevated (>4.0 ng/mL) vs. low/normal (≤4.0 ng/mL).
Monitoring of C-peptide, HbA1c, and eGFR post-transplant.

Main Results:

Disparate post-transplant C-peptide trends observed between elevated and low/normal pre-transplant groups.
Elevated pre-transplant C-peptide group showed an unexpected decline in post-transplant C-peptide levels.
Both groups achieved normoglycemic control (HbA1c ~5.2%).

Conclusions:

Post-transplant C-peptide dynamics are complex, with unexpected patterns in recipients with elevated pre-transplant levels.
Pre-transplant C-peptide levels may not be a reliable predictor of pancreas transplant outcomes.
Further research is needed to understand post-transplant C-peptide metabolism.