Janus-Structured Micro/Nanomotors: Self-Propelled Mechanisms and Biomedical Applications

Self-propelled micro/nanomotors (MNMs), which can convert other energy into mechanical motion, have attracted considerable attention due to their potential applications in diverse fields. Due to the asymmetric structures and 2 or more chemically discrepant composites constructed in the Janus nanoparticles, asymmetrical forces can be created in the physical environment. Thus, MNMs with Janus structures have been widely studied for revealing possible driving mechanisms. This tutorial review covers the most representative examples of Janus-structured MNMs developed so far, which are self-propelled by different mechanisms. We focus on Janus MNMs that exhibit self-propelled motion in liquid environments and their potential applications in biomedicine, including drug delivery, cancer therapy, bioimaging, and biosensing. The driving mechanisms and challenges associated with constructing asymmetric fields are deeply discussed, along with future opportunities for these versatile and promising MNMs. This review provides an overview of the rapidly evolving field of MNMs and their potential applications, serving as a valuable resource for researchers and others interested in this field.