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Updated: May 15, 2025

Generation of Organ-conditioned Media and Applications for Studying Organ-specific Influences on Breast Cancer Metastatic Behavior
Published on: June 13, 2016
Premetastatic niche mechanics and organotropism in breast cancer
Sarah Libring1, Cynthia A Reinhart-King1
1Department of Bioengineering, Rice University, Houston, TX USA.
Abstract:
Numerous physical and mechanical changes occur in the premetastatic niche. Here, we review the mechanics of the premetastatic niche and how the altered extracellular matrix and cancer cell mechanics may play a role in organotropism in breast cancer. Future research into premetastatic niche development and organotropic cell behavior should address physical alterations and biomechanical effects to the same rigor that biochemical alterations are studied.
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