Exploration of SUSD3 in pan-cancer: studying its role, predictive analysis, and biological significance in various malignant tumors in humans
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View abstract on PubMed
Summary
This summary is machine-generated.Sushi domain containing 3 (SUSD3) protein expression is linked to cancer progression and patient prognosis. Targeting SUSD3 offers a promising strategy for novel cancer therapies and diagnostics.
Area Of Science
- Oncology
- Immunology
- Molecular Biology
Background
- The SUSD3 protein, characterized by its Sushi domain, is implicated in cancer progression, with expression levels correlating to tumor advancement and patient outcomes.
- Altered SUSD3 expression may serve as a predictive biomarker for cancer progression, and it is recognized as a novel susceptibility marker.
- SUSD3 presents a promising target for antibody-based therapies, potentially aiding in the prevention, diagnosis, and treatment of breast cancer.
Purpose Of The Study
- To investigate the role of SUSD3 protein in various cancers and its potential as a therapeutic target.
- To analyze SUSD3 expression patterns in different tissues and cell types within the tumor microenvironment.
- To explore the prognostic significance and predictive value of SUSD3 in cancer immunotherapy.
Main Methods
- Utilized HPA, GeneMANIA, The Cancer Genome Atlas, TISCH, and STOmics DB for expression analysis and tissue distribution.
- Assessed prognostic significance using univariate Cox regression and explored genomic alterations via cBioPortal.
- Investigated immunotherapy response, biological pathways (GSEA/GSVA), drug targets (CellMiner, CTRP, GDSC), and performed molecular docking and in vitro knockdown experiments.
Main Results
- SUSD3 expression variations correlate with prognosis across multiple cancer types and are predominantly found in monocytes/macrophages and CD4+ T cells within the tumor microenvironment.
- A strong association exists between SUSD3 expression, cancer immunotherapy biomarkers, immune cell infiltration, and immunomodulatory factors.
- SUSD3 knockdown in breast cancer cells significantly inhibited proliferation and migration, with selumetinib identified as a potential inhibitor via molecular docking.
Conclusions
- The study establishes a foundation for understanding SUSD3's role in pan-carcinomas, highlighting its immune regulatory functions.
- Findings offer novel perspectives and potential therapeutic targets for developing innovative cancer treatment strategies.
- SUSD3's involvement in cancer progression and its interaction with the immune system underscore its potential as a target for novel therapies.
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