Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Surface Membrane Barriers

Surface Membrane Barriers

The skin and mucous membranes serve as the primary line of defense against pathogens by providing both physical and chemical protection. These barriers are essential in preventing the entry and establishment of microbes, thereby maintaining the integrity of the host.
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Revealing the Effects of Process Parameters on Structural, Thermal, Mechanical, Biodegradation, and Biocompatibility Properties on the Electrospinning of Poly(vinyl alcohol)/Microbial Inulin Nanofibers.

ACS omega·2026

Same author

Engineered acetylated inulin nanoparticles for enhanced oral insulin delivery: sustained release, structural stability, and <i>in vivo</i> efficacy.

RSC advances·2025

Same author

Study on the development of nanoparticles based on levan for oral insulin delivery.

Biomedical materials (Bristol, England)·2025

Same author

Development of inulin nanocarrier for effective oral delivery of insulin: synthesize, optimization, characterization, and biophysical study.

Journal of biomaterials science. Polymer edition·2024

Same author

Designing a Novel Multiepitope Vaccine from the Human Papilloma Virus E1 and E2 Proteins for Indonesia with Immunoinformatics and Molecular Dynamics Approaches.

ACS omega·2024

Same author

Synthesis of pyridinium-based ionic liquids and their application to improve <i>Candida rugosa</i> lipase stability in a methanol-water solvent system.

Turkish journal of chemistry·2023

Search research articles

Related Experiment Video

Updated: May 15, 2025

PLGA Nanoparticles Formed by Single- or Double-emulsion with Vitamin E-TPGS

PLGA Nanoparticles Formed by Single- or Double-emulsion with Vitamin E-TPGS

Published on: December 27, 2013

Rhamnolipid-Modified PHB-Ectoine Nanoparticles for Multifunctional Skin Protection Against UVB, Irritation, and

Alma Tyara Simbara¹, Fera Faridatul Habibah¹, Rukman Hertadi¹

¹Biochemistry and Biomolecular Engineering Research Division, Faculty of Mathematics and Natural Sciences, Bandung Institute of Technology, Jl. Ganesa No.10, Bandung 40132, Indonesia.

|April 7, 2025

Summary

This study developed a novel nanoformulation using poly(R)-3-hydroxybutyrate (PHB) and ectoine, enhanced with rhamnolipid, demonstrating significant anti-UVB and anti-irritation skin protection. The formulation also exhibited antibacterial properties against Staphylococcus aureus.

More Related Videos

Biofunctionalized Prussian Blue Nanoparticles for Multimodal Molecular Imaging Applications

Biofunctionalized Prussian Blue Nanoparticles for Multimodal Molecular Imaging Applications

Published on: April 28, 2015

Preparation and Characterization of Novel HDL-mimicking Nanoparticles for Nerve Growth Factor Encapsulation

Preparation and Characterization of Novel HDL-mimicking Nanoparticles for Nerve Growth Factor Encapsulation

Published on: May 22, 2017

Related Experiment Videos

Last Updated: May 15, 2025

PLGA Nanoparticles Formed by Single- or Double-emulsion with Vitamin E-TPGS

PLGA Nanoparticles Formed by Single- or Double-emulsion with Vitamin E-TPGS

Published on: December 27, 2013

Biofunctionalized Prussian Blue Nanoparticles for Multimodal Molecular Imaging Applications

Biofunctionalized Prussian Blue Nanoparticles for Multimodal Molecular Imaging Applications

Published on: April 28, 2015

Preparation and Characterization of Novel HDL-mimicking Nanoparticles for Nerve Growth Factor Encapsulation

Preparation and Characterization of Novel HDL-mimicking Nanoparticles for Nerve Growth Factor Encapsulation

Published on: May 22, 2017

Area of Science:

Biomaterials Science
Nanotechnology
Dermatology

Background:

Rhamnolipid, poly(R)-3-hydroxybutyrate (PHB), and ectoine are biocompatible compounds with skin-protective benefits.
These sustainable compounds are utilized in skincare products for their unique properties.

Purpose of the Study:

To synthesize and characterize nanoparticles from PHB and ectoine for multifunctional skin protection.
To evaluate the anti-UVB and anti-irritation efficacy of the novel nanoformulation.

Main Methods:

Covalent bonding of PHB and ectoine using EDC, followed by nanoparticle synthesis via centrifugation.
Physicochemical characterization of the synthesized nanoparticles (PHB-ectoine NPs).
In vitro testing for anti-irritation and anti-UVB activity, and antibacterial properties with rhamnolipid.

Main Results:

Spherical PHB-ectoine NPs (527 ± 228 nm) with a layered structure were synthesized.
The nanoparticles showed over 10-fold higher anti-irritant and 4-fold higher anti-UVB activity than PHB alone.
The rhamnolipid-enhanced formulation exhibited antibacterial activity against Staphylococcus aureus.

Conclusions:

The rhamnolipid-PHB-ectoine nanoformulation is a promising multifunctional agent for skin protection.
The formulation offers significant anti-UVB, anti-irritation, and antibacterial capabilities.
This development holds potential for advanced skincare and dermatological applications.