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Engineering Antiviral Agents via Surface Plasmon Resonance

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Rerouting therapeutic peptides and unlocking their potential against SARS-CoV2.

Namrata Prashar¹, Saharuddin Bin Mohammed², N S Raja³

¹Bioinformatics and Entomoinformatics Lab, Department of Genetic Engineering, College of Engineering and Technology, SRM Institute of Science and Technology, Kattankulathur, Chengalpattu, Chennai, Tamil Nadu 603203 India.

|April 7, 2025

Summary

Therapeutic peptides show promise for treating viral infections like COVID-19 by modulating immune responses and inhibiting viral replication. Advancements in AI and computational modeling will accelerate the development of peptide therapies for future pandemic preparedness.

Keywords:

Antiviral peptides Immunomodulatory peptides Multipurpose peptides Peptide inhibitors Peptide repurposing SARS-CoV-2 Sustainable Development Goals

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A Fluorogenic Peptide Cleavage Assay to Screen for Proteolytic Activity: Applications for coronavirus spike protein activation

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Area of Science:

Virology
Immunology
Drug Discovery
Computational Biology

Background:

The COVID-19 pandemic underscored the need for novel therapeutic strategies against SARS-CoV-2.
Traditional pharmaceuticals face challenges in combating rapidly mutating viruses.
Peptide-based therapies offer a potential alternative with diverse mechanisms of action.

Purpose of the Study:

To review the role of therapeutic peptides in antiviral defense against SARS-CoV-2 and its variants.
To explore peptide applications in immune modulation, viral entry inhibition, and replication disruption.
To assess the potential of peptide therapies in future pandemic preparedness.

Main Methods:

Literature review of existing research on peptide-based antiviral therapies.
Analysis of studies focusing on peptide mechanisms against SARS-CoV-2.
Exploration of advancements in computational modeling and artificial intelligence for peptide drug discovery.

Main Results:

Therapeutic peptides demonstrate efficacy in modulating immune responses and inhibiting viral replication.
Challenges include peptide stability, bioavailability, and viral mutation rates.
Ongoing research and clinical trials indicate growing integration of peptide treatments.

Conclusions:

Peptide-based therapies are a critical and promising component of future pandemic preparedness.
AI and computational modeling will enhance peptide screening and repurposing strategies.
Peptides offer a viable alternative or adjunct to traditional treatments for viral outbreaks.