Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Diamagnetic Shielding of Nuclei: Local Diamagnetic Current01:14

Diamagnetic Shielding of Nuclei: Local Diamagnetic Current

1.3K
An applied magnetic field causes the electrons present in the molecule to circulate, setting up a local diamagnetic current within the molecule. The local diamagnetic current arising from circulating sigma-bonding electrons induces a magnetic field, Blocal that opposes the applied magnetic field, B0. The effective magnetic field experienced by these nuclei is given by the difference between the applied and local magnetic fields in a phenomenon called local diamagnetic shielding. Essentially,...
1.3K
Ethical Standards I01:25

Ethical Standards I

1.5K
The American Nurses Association (ANA) created and implemented the first nationally accepted Code of Ethics for Nurses with Interpretive Statements. The Code of Ethics is a living document regularly updated by the ANA and establishes an ethical standard that is non-negotiable for nurses in all roles and settings.
The Code of Ethics provisions outline the nurse's duty to the patient, the healthcare team, the profession, and society. The Code's fundamental principles include advocacy,...
1.5K
Deleterious Substances in Aggregate01:25

Deleterious Substances in Aggregate

867
Deleterious substances in aggregates can be detrimental to the quality and durability of concrete. These substances include organic impurities like loam, which interfere with cement hydration and are usually present in the sand. These prevent a good bond between aggregate and cement paste. Organic impurities can be detected using the colorimetric test, where the darkness of a solution after agitation indicates the level of organic content.
Another type of impurity is clay and fine material that...
867
Strategies for Assessing and Addressing Confounding01:25

Strategies for Assessing and Addressing Confounding

596
Confounding is a critical issue in epidemiological studies, often leading to misleading conclusions about associations between exposures and outcomes. It occurs when the relationship between the exposure and the outcome is mixed with the effects of other factors that influence the outcome. Given that, addressing confounding is of high importance for drawing accurate inferences in research.
Confounding can be addressed at both the design phase of a study and through analytical methods after data...
596
Censoring Survival Data01:09

Censoring Survival Data

689
Survival analysis is a statistical method used to analyze time-to-event data, often employed in fields such as medicine, engineering, and social sciences. One of the key challenges in survival analysis is dealing with incomplete data, a phenomenon known as "censoring." Censoring occurs when the event of interest (such as death, relapse, or system failure) has not occurred for some individuals by the end of the study period or is otherwise unobservable, and it might have many different...
689

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Body dissatisfaction and adolescence suicidality - results from the Danish national birth cohort.

Journal of psychiatric research·2026
Same author

Determinants of body mass index during early life: findings from an exposome-wide association study with follow-up replication and Mendelian randomization analyses.

Exposome·2026
Same author

Commentary: Optimising neonatal transport team quality metrics.

Pediatric research·2026
Same author

Data-driven model reveals increased stability of CAG-expanded huntingtin RNA due to MID1 binding.

PLoS computational biology·2026
Same author

Pubertal timing and tempo and depression risk in adolescent boys and girls: A Danish population-based cohort study.

Journal of affective disorders·2026
Same author

Associations of ambient temperature exposure with embryonic and early fetal development.

International journal of epidemiology·2026
Same journal

metaLoc: protein localisation prediction workflow.

Bioinformatics advances·2026
Same journal

Fuscan: a robust DNA fusion caller for targeted sequencing data in cancer diagnostics.

Bioinformatics advances·2026
Same journal

Correction to: Pathogenicity patterns in cytochrome P450 family.

Bioinformatics advances·2026
Same journal

Region-aware bridge modeling enables interpretable mesoscale representation of spatial transcriptomic tissue sections.

Bioinformatics advances·2026
Same journal

Microbiome differential abundance methodologies to detect relevant taxa associated with chemotherapy toxicity rate in colorectal cancer.

Bioinformatics advances·2026
Same journal

maldipickr dereplicates microbial MALDI-TOF spectra to facilitate multiplexed isolation.

Bioinformatics advances·2026
See all related articles

Related Experiment Video

Updated: May 4, 2026

The MPLEx Protocol for Multi-omic Analyses of Soil Samples
10:12

The MPLEx Protocol for Multi-omic Analyses of Soil Samples

Published on: May 30, 2018

10.9K

DataSHIELD: mitigating disclosure risk in a multi-site federated analysis platform.

Demetris Avraam1,2, Rebecca C Wilson2, Noemi Aguirre Chan3

  • 1Department of Public Health, Section of Epidemiology, University of Copenhagen, Copenhagen, DK-1353, Denmark.

Bioinformatics Advances
|April 7, 2025
PubMed
Summary
This summary is machine-generated.

DataSHIELD enables federated analysis for large-scale health data, enhancing findings validity. This open-source platform ensures data security and privacy through multi-layered disclosure prevention mechanisms.

More Related Videos

Integrating Computerized Linguistic and Social Network Analyses to Capture Addiction Recovery Capital in an Online Community
08:53

Integrating Computerized Linguistic and Social Network Analyses to Capture Addiction Recovery Capital in an Online Community

Published on: May 31, 2019

5.1K
Implementation of a Real-Time Psychosis Risk Detection and Alerting System Based on Electronic Health Records using CogStack
07:31

Implementation of a Real-Time Psychosis Risk Detection and Alerting System Based on Electronic Health Records using CogStack

Published on: May 15, 2020

7.0K

Related Experiment Videos

Last Updated: May 4, 2026

The MPLEx Protocol for Multi-omic Analyses of Soil Samples
10:12

The MPLEx Protocol for Multi-omic Analyses of Soil Samples

Published on: May 30, 2018

10.9K
Integrating Computerized Linguistic and Social Network Analyses to Capture Addiction Recovery Capital in an Online Community
08:53

Integrating Computerized Linguistic and Social Network Analyses to Capture Addiction Recovery Capital in an Online Community

Published on: May 31, 2019

5.1K
Implementation of a Real-Time Psychosis Risk Detection and Alerting System Based on Electronic Health Records using CogStack
07:31

Implementation of a Real-Time Psychosis Risk Detection and Alerting System Based on Electronic Health Records using CogStack

Published on: May 15, 2020

7.0K

Area of Science:

  • Biomedical Informatics
  • Epidemiology
  • Data Governance

Background:

  • Epidemiologic findings' validity relies on data triangulation and large datasets.
  • Access to health and biomedical data is often restricted by practical, ethico-legal, and governance constraints.
  • Data access requests across jurisdictions are time-consuming due to governance requirements.

Purpose of the Study:

  • To describe the disclosure protection system of DataSHIELD.
  • To present DataSHIELD as a solution for large-scale statistical analysis of health and biomedical data.
  • To highlight DataSHIELD's capabilities in addressing technical and regulatory challenges in data analysis.

Main Methods:

  • DataSHIELD employs federated analysis, enabling remote data analysis without data transfer.
  • The platform is aligned with the 'Five Safes' framework for secure data research access.
  • A multi-layer system of disclosure-preventing mechanisms mitigates disclosure risk during real-time analysis.

Main Results:

  • DataSHIELD provides real-time remote statistical analysis.
  • Disclosure prevention mechanisms are integrated across system, analysis, and governance levels.
  • The software facilitates large-scale statistical analysis of health and biomedical data while adhering to data governance.

Conclusions:

  • DataSHIELD offers a robust solution for secure, federated analysis of sensitive health data.
  • The platform addresses challenges in data access and governance for large-scale research.
  • DataSHIELD enhances the validity of epidemiologic findings through secure data analysis.