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Relationship between patent ductus arteriosus and platelet indices in newborn: a systematic review and meta-analysis
Yanbing An1, Gaowa Arigong1, Wuyun Zhao2
1Department of Neonatology, Inner Mongolia Maternal and Child Health Hospital, Hohhot, China.
Insights
Newborns with patent ductus arteriosus (PDA) may show lower platelet count and plateletcrit, but higher platelet large cell ratio. These platelet index changes offer insights for early PDA detection and management.
Area of Science:
- Neonatal Medicine
- Hematology
- Pediatric Cardiology
Background:
- Investigating platelet indices in neonates is crucial for understanding early life health.
- Patent Ductus Arteriosus (PDA) is a common neonatal condition requiring early diagnosis.
- The association between platelet parameters and PDA requires further clarification.
Purpose of the Study:
- To examine the relationship between patent ductus arteriosus (PDA) and various platelet indices in newborns.
- To synthesize existing evidence on platelet count, plateletcrit, and other platelet markers in neonates with PDA.
Main Methods:
- A systematic review and meta-analysis were conducted.
- Searched major Chinese and international databases up to January 31, 2024.
- Included 32 relevant studies (20 English, 12 Chinese).
Main Results:
- Neonates with PDA showed significantly lower platelet count (PLT) and plateletcrit (PCT).
- A higher platelet large cell ratio (P-LCR) was observed in neonates with PDA.
- Platelet mass, PDW, and MPV did not show significant differences between groups.
Conclusions:
- Decreased PLT and PCT, along with increased P-LCR, may characterize neonates with PDA.
- These altered platelet indices could serve as potential biomarkers for early PDA identification and assessment.
- Understanding these hematological shifts aids in personalized treatment strategies for neonatal PDA.
Background:
The role of platelet indices in the early hours of life and their potential association with patent ductus arteriosus (PDA) have been subjects of investigation in recent studies. This study aimed to investigate the relationship between PAD and platelet indices in newborn.
Methods:
A systematic review and meta-analysis and were preformed based on Chinese databases CNKI and Wanfang database, as well as the international databases PubMed, Web of Science, Cochrane Library, and Embase from their inception to January 31, 2024.
Results:
This study included 32 literatures, with 20 of English and 12 of Chinese ones. The meta regression analysis showed that neonates with PDA tend to exhibit lower platelet count (PLT) and plateletcrit (PCT), as well as higher platelet large cell ratio (P-LCR) (all P < 0.05), while platelet mass, platelet distribution width (PDW), and mean platelet volume (MPV) remain comparable (all P > 0.05).
Conclusion:
PDA neonates might have decreased PLT and PCT, while increased P-LCR. These dynamic shifts in platelet indices provide fresh insights into the pathophysiology of PDA and have potential to serve as important indicators for early identification, disease assessment, and personalized treatment decisions in clinical practice.
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