Related Experiment Video

Updated: May 17, 2025

Yeast As a Chassis for Developing Functional Assays to Study Human P53
14:57

Yeast As a Chassis for Developing Functional Assays to Study Human P53

Published on: August 4, 2019

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p53: A player in the tumor microenvironment

Shuang Zhao1, Hongyong Wen2, Baiqi Wang2

  • 1Hunan Engineering Research Center for Early Diagnosis and Treatment of Liver Cancer, Cancer Research Institute, Hengyang Medical School, University of South China, Hengyang, 421001, China.

Oncology Research
|April 7, 2025
PubMed

Insights

The tumor suppressor protein p53 plays a crucial role in cancer by interacting with the tumor microenvironment (TME). Understanding p53

Area of Science:

  • Oncology
  • Cancer Biology
  • Immunology

Background:

  • TP53 gene mutations are found in approximately 50% of human cancers.
  • The p53 pathway is frequently inactivated in malignancies through various mechanisms.
  • The tumor microenvironment (TME) significantly impacts tumor progression, metastasis, and patient prognosis.

Purpose of the Study:

  • To review the intricate interactions between p53 and the tumor microenvironment.
  • To elucidate the mechanisms by which p53 influences the TME and host immunity.
  • To provide insights into drug development and clinical studies targeting the p53-TME axis.

Main Methods:

  • Literature review of existing research on p53 and TME.
  • Analysis of studies investigating p53's role in immune cell function within the TME.
  • Synthesis of data on the impact of p53 status on tumor progression and metastasis.

Main Results:

  • p53 status influences immune cell infiltration and function within the TME.
  • Aberrant p53 can promote tumor development and metastasis by modulating TME components.
  • Specific mechanisms of p53-TME interaction are being actively investigated.

Conclusions:

  • p53 is a key regulator of the tumor immune microenvironment.
  • Targeting the p53 pathway in conjunction with the TME holds therapeutic potential.
  • Further research is crucial to fully understand and exploit the p53-TME relationship for cancer treatment.
Keywords:
Cancer therapyMutant p53Tumor microenvironment (TME)Wild type p53p53

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