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Genetically Predicted Causal Relationship between Gut Microbiota and Various Kidney Diseases
Zi-Jin Chen1, Rui Wang2, Meng-Ying Yao1
1Department of Nephrology, Chongqing Key Laboratory of Prevention and Treatment of Kidney Disease, Chongqing Clinical Research Center of Kidney and Urology Diseases, Xinqiao Hospital, Army Medical University (Third Military Medical University), Chongqing, China.
Kidney Diseases (Basel, Switzerland)
|April 7, 2025
Summary
This study used mendelian randomization to explore gut microbiota
Area of Science:
- Microbiology
- Genetics
- Nephrology
Background:
- Alterations in gut microbiota are implicated in kidney disease pathophysiology.
- The causal links between specific gut bacteria and kidney disease risk are not well understood.
Purpose of the Study:
- To investigate the causal relationships between gut microbiota and three kidney diseases: diabetic nephropathy, IgA nephropathy, and membranous nephropathy.
- To explore the role of immune infiltration in these kidney diseases.
Main Methods:
- Utilized large-scale genome-wide association studies summary data for gut microbiota and kidney diseases.
- Employed inverse variance weighted (IVW) method for Mendelian randomization analysis.
- Conducted sensitivity analyses including heterogeneity and pleiotropy tests, and reverse Mendelian randomization.
Main Results:
- Identified several specific gut bacteria causally associated with kidney disease risk.
- Found protective effects of *Dialister* on diabetic nephropathy and *Clostridium innocuum* on IgA nephropathy.
- Identified multiple risk factors for IgA nephropathy and membranous nephropathy, and protective factors for membranous nephropathy.
- Confirmed robustness of findings through sensitivity analyses and noted distinct immune cell distributions.
Conclusions:
- Established causal links between specific gut microbiota and the risk of diabetic nephropathy, IgA nephropathy, and membranous nephropathy.
- Findings offer new insights into microbial contributions to kidney diseases, supporting further clinical research.
- Highlighted the significance of immunological processes in kidney disease development.
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