[Lung function and ethnicity: comments on race-neutral reference equations]
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Updated: May 17, 2025

Phenotyping Mouse Pulmonary Function In Vivo with the Lung Diffusing Capacity
Published on: January 6, 2015
1Amsterdam UMC, afd. Longgeneeskunde, Amsterdam.
Abstract:
Recently, race-neutral reference equations have been published for spirometry, based on a large international reference population ('Global Lung Initiative'). Analysis of demographic data in the USA shows that this may have negative consequences for some groups, compared with race-specific reference equations. De underlying question remains whether ethnic differences exist in lung function. Most measurements have been performed in people of North-European ancestry and are therefore probably not representative for the rest of the world. A more representative study is warranted. Ideally, we can find out which factors determine possible differences between ethnic groups, so that spirometry values can be corrected for these factors.
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