[Lung function and ethnicity: comments on race-neutral reference equations].

Area of Science:

• Pulmonary Medicine
• Clinical Physiology
• Population Health

Context:

• Recent publication of race-neutral spirometry reference equations (Global Lung Initiative).
• Analysis indicates potential negative consequences for specific demographic groups in the USA compared to race-specific equations.
• Current reference data predominantly from North-European ancestry, limiting global applicability.

Purpose:

• To investigate the existence of ethnic differences in lung function.
• To identify factors contributing to ethnic variations in spirometry.
• To inform the development of more representative and equitable lung function assessment tools.

Summary:

• Race-neutral spirometry equations may not be universally applicable, potentially disadvantaging certain populations.
• Existing lung function data is not representative of the global population.
• There is a need for studies that explore ethnic variations in lung function and their underlying determinants.

Impact:

• Highlights the potential for health disparities due to non-representative spirometry data.
• Underscores the importance of ethnic diversity in clinical reference standards.
• Advocates for research to refine spirometry interpretation for diverse ethnic groups, ensuring accurate diagnosis and treatment.