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Barrett's Esophagus in Time and Space: A Methylation Panel for Tracking Esophageal Cancer

Daniel H Jacobson1, Rebecca C Fitzgerald

  • 1Department of Oncology, Early Cancer Institute, University of Cambridge, Cambridge, UK.

The American Journal of Gastroenterology
|April 7, 2025
PubMed
Abstract

No abstract available in PubMed .

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Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
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Barrett Esophagus-II: Clinical Manifestations and Management01:21

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Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
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