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Re-engineering bone: pathogenesis, diagnosis and emerging therapies for osteoporosis
Xinyi Dong1,2, Hao Liu1,2, Dian Yuan3
1Central Laboratory, Peking University School and Hospital of Stomatology, Beijing 100081, China. orthoyan@bjmu.edu.cn.
Journal of Materials Chemistry. B
|April 7, 2025
Summary
Tissue engineering offers a promising alternative to traditional osteoporosis treatments by addressing the disease's complex pathogenesis. This review explores advanced biomaterials and therapies for improved osteoporosis management.
Area of Science:
- Biomedical Engineering
- Regenerative Medicine
- Orthopedics
Background:
- Osteoporosis is a prevalent metabolic bone disease with significant healthcare implications.
- Traditional pharmacotherapy for osteoporosis has limitations, driving the need for alternative treatments.
- Understanding the pathogenesis, including abnormal microenvironments, is crucial for developing effective strategies.
Purpose of the Study:
- To review the pathogenesis of osteoporosis and current diagnostic techniques.
- To evaluate advanced tissue engineering strategies for osteoporosis treatment.
- To provide insights into future directions for tissue engineering-based osteoporosis management.
Main Methods:
- Comprehensive literature review of osteoporosis pathogenesis and diagnostics.
- Analysis of tissue engineering approaches, including delivery systems (hydrogels, nanomaterials).
- Evaluation of bone tissue engineering materials (ceramics, cements, polymers) and bioactive substances (exosomes, cytokines).
Main Results:
- Tissue engineering presents a viable alternative to conventional osteoporosis treatments.
- Various biomaterials and delivery systems show potential for bone regeneration.
- Emerging therapies include exosomes, cytokines, and small-molecule drugs.
Conclusions:
- Tissue engineering strategies offer innovative solutions for osteoporosis management.
- Further research into biomaterials and therapeutic approaches is needed for clinical translation.
- This review synthesizes current advancements to guide future research and clinical applications.
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