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Updated: Aug 13, 2026

Assessment of Right Ventricular Structure and Function in Mouse Model of Pulmonary Artery Constriction by Transthoracic Echocardiography
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Longitudinal Trajectory of Left Ventricular Systolic Function in Children During Anthracycline-Based Chemotherapy

Shanshan Li1, Yanxiang Wu1, Jingya Li1

  • 1Department of Echocardiography, Heart Center, National Center for Children's Health, Beijing Children's Hospital, Capital Medical University, Beijing, China.

Echocardiography (Mount Kisco, N.Y.)
|April 7, 2025
PubMed

Insights

Noninvasive myocardial work indices (MWIs) show worsening during chemotherapy, offering a sensitive measure of anthracycline-induced cardiotoxicity in children. These findings aid in timely interventions to prevent cardiac dysfunction.

Area of Science:

  • Cardiology
  • Pediatric Oncology
  • Echocardiography

Background:

  • Noninvasive myocardial work (MW) assesses left ventricular (LV) systolic function.
  • Longitudinal changes in MW indices (MWIs) during anthracycline chemotherapy in children are not well understood.

Purpose of the Study:

  • To track MWIs during anthracycline chemotherapy in pediatric patients.
  • To compare MWIs with conventional echocardiographic parameters.

Main Methods:

  • Retrospective analysis of 441 echocardiograms from 102 children receiving anthracycline treatment.
  • Measurement of LV ejection fraction (LVEF), global longitudinal strain (GLS), and MWIs (GWI, GCW, GWE, GWW).

Main Results:

  • GLS, GWI, GCW, and GWE declined during chemotherapy, with deterioration noted at 30-60 mg/m² cumulative anthracycline dose.
  • LVEF and GWW showed no significant trends.
  • GWI and GCW changes were more pronounced than GLS and GWE changes.

Conclusions:

  • Echocardiographic MW provides sensitive assessment of anthracycline-induced cardiotoxicity (AIC) in children.
  • Early detection of cardiotoxicity allows for timely chemotherapy adjustments or cardioprotective strategies.
  • MWIs can help prevent cardiac dysfunction in pediatric cancer patients.
Abstract

Keywords:
cardiotoxicitychemotherapyechocardiographymyocardial workpressure–strain loop

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