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Published on: February 16, 2020
Infrared Irradiation-Assisted Green Approach for Pd-Catalyzed Buchwald-Hartwig Amination
Ambra Maria Fiore1, Riccardo Ciciriello1, Davide Blasi1
1Dipartimento di Chimica, Università degli Studi di Bari Aldo Moro, Via Edoardo Orabona 4, Bari, 70126, Italy.
Abstract:
We report a novel and green approach for Pd-catalyzed Buchwald-Hartwig amination, assisted by Infrared (IR) irradiation under quasi-solvent-free conditions, in a nonanhydrous environment, and without the exclusion of air. The C-N coupling reactions, performed with a stoichiometric amount of cyclopentyl methyl ether, proceed with moderate-to-good yields using aryl iodides and bromides bearing both electron-donating and electron-withdrawing groups, along with a variety of secondary and primary amines.
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