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Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

482
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
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Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

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Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
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Risk Score Predicting Primary Open-Angle Glaucoma Patients With Vascular Predisposition.

Nana Takahashi1, Yukihiro Shiga1,2,3, Naoki Kiyota1

  • 1Department of Ophthalmology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan.

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Summary

A questionnaire identifies patients with primary open-angle glaucoma (POAG) who have vascular issues. This risk score helps detect reduced optic nerve head blood flow during cold stress, aiding personalized glaucoma care.

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Area of Science:

  • Ophthalmology
  • Vascular Biology
  • Glaucoma Research

Background:

  • Primary open-angle glaucoma (POAG) is a leading cause of irreversible blindness.
  • Vascular dysregulation is increasingly recognized as a contributing factor in glaucoma pathogenesis.
  • Identifying patients with vascular predisposition is crucial for targeted interventions.

Purpose of the Study:

  • To evaluate the Flammer Syndrome Questionnaire (FSQ) risk score's ability to predict POAG prevalence in patients with vascular predisposition.
  • To assess optic nerve head (ONH) blood flow changes in Flammer syndrome (FS) using laser speckle flowgraphy (LSFG).
  • To examine the association between ONH blood flow and the FSQ risk score during cold provocation in normal-tension glaucoma (NTG).

Main Methods:

  • Administered the FSQ to 823 healthy subjects and 512 POAG patients to determine vascular risk scores.
  • Utilized LSFG to measure ONH blood flow pulsatility in 358 eyes of 206 NTG patients with FS.
  • Correlated Mean blur rate (MBRAve) changes during cold provocation with FSQ risk scores in 56 NTG eyes.

Main Results:

  • Five FSQ symptoms (cold extremities, low BP, drug sensitivity, underweight, perfectionism) were significantly associated with POAG.
  • The FSQ vascular risk score effectively differentiated healthy individuals from NTG patients (AUC = 0.73).
  • FS patients exhibited greater ONH pulsatility, and higher FSQ scores correlated with reduced cold-induced ONH blood flow in NTG eyes (r = -0.41).

Conclusions:

  • The FSQ serves as a valuable screening tool for identifying POAG patients with vascular stiffness and reduced ONH blood flow under cold stress.
  • The FSQ risk score can aid in tailoring individualized glaucoma management strategies.
  • This approach enhances the understanding of vascular contributions to glaucoma and informs clinical practice.