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Related Experiment Videos

Effect of ascorbic acid supplementation on selenium bioavailability in humans.

M Mutanen, H M Mykkänen

    Human Nutrition. Clinical Nutrition
    |May 1, 1985
    PubMed
    Summary

    Supplemental ascorbic acid may enhance selenium (Se) absorption from food, but not from sodium selenate supplements. This suggests dietary selenium bioavailability depends on the chemical form ingested.

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    Area of Science:

    • Human Nutrition
    • Biochemistry
    • Trace Element Metabolism

    Background:

    • Selenium (Se) is an essential trace element crucial for various physiological functions.
    • Ascorbic acid (vitamin C) is a potent antioxidant with potential roles in nutrient absorption.
    • Understanding the interaction between ascorbic acid and selenium bioavailability is important for optimizing Se status.

    Purpose of the Study:

    • To investigate the impact of supplemental ascorbic acid on selenium bioavailability in humans.
    • To assess whether ascorbic acid influences the absorption of different forms of selenium.
    • To determine the effect on plasma selenium levels and glutathione peroxidase activity.

    Main Methods:

    • A 4-week supplementation study involving three groups of female university students.
    • Groups received either sodium selenate, sodium selenate plus ascorbic acid, or ascorbic acid alone.
    • Plasma selenium levels and plasma glutathione peroxidase (GSH-Px) activity were measured as indicators of Se status.

    Main Results:

    • Plasma Se levels significantly increased in all supplemented groups.
    • The highest increase in plasma Se was observed in the group receiving both Se and ascorbic acid.
    • Ascorbic acid did not significantly affect the bioavailability of supplemental sodium selenate, but influenced plasma GSH-Px activity.

    Conclusions:

    • Supplemental ascorbic acid may improve the bioavailability of naturally occurring selenium in foods.
    • The effect of ascorbic acid on selenium bioavailability appears to be dependent on the specific selenium compound ingested.
    • Further research is needed to elucidate the mechanisms underlying this interaction.

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