Related Experiment Video

Updated: Jun 13, 2025

Assessment of Resistance to Tyrosine Kinase Inhibitors by an Interrogation of Signal Transduction Pathways by Antibody Arrays
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Assessment of Resistance to Tyrosine Kinase Inhibitors by an Interrogation of Signal Transduction Pathways by Antibody Arrays

Published on: September 19, 2018

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Molecular response with asciminib 20 mg QD in a patient intolerant to multiple TKIs

Ruth Stuckey1, Laura Navarrete Bullón1, Asunción Borrero Borrego2,3

  • 1Hematology Department, Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas, Spain.

Annals of Hematology
|April 7, 2025
PubMed

Insights

A young patient with chronic myeloid leukemia (CML) achieved major molecular response (MMR) using a low dose of asciminib, overcoming intolerance to other treatments. This demonstrates the drug

Area of Science:

  • Hematology
  • Oncology
  • Pharmacology

Background:

  • Chronic myeloid leukemia (CML) treatment often involves tyrosine kinase inhibitors (TKIs).
  • Patient intolerance and resistance to standard TKI doses present significant treatment challenges.
  • Asciminib is a novel TKI targeting the BCR-ABL1 protein in CML.
Keywords:
AsciminibCytopeniaSubtherapeutic dosingTyrosine kinase inhibitors (TKIs)

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