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Erlotinib-Conjugated O-Phenylenediamine Derived Fluorescent Carbon Nanodots (OPD@CD) Platform for Targeting Breast
Ali Ibrahim Shkhair1,2, Anju S Madanan1, Susan Varghese1
1Department of Chemistry, School of Physical and Mathematical Sciences, University of Kerala, Kariavattom Campus, Thiruvananthapuram, Kerala, 695581, India.
Abstract:
Breast cancer continues to be a complicated and pervasive health issue that impacts women worldwide. Fluorescent nanoparticles, in particular, provide significant potential for imaging and drug delivery in cancer cells. We describe the utilization of o-phenylenediamine carbon nanodots (OPD@CD) as fluorescent agents for in vitro imaging and drug delivery of breast cancer cells. The surface of OPD@CD was modified with the tyrosine kinase inhibition anticancer drug - erlotinib. The drug specifically targets human breast cancer cell lines (MCF-7) that overexpress the epidermal growth factor receptor (EGFR). The confocal luminescence microscopic photographs exhibit sufficient luminescence staining in MCF-7 cells.
