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Updated: May 17, 2025

In Vitro Thrombosis Test for Ventricular Assist Devices
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In Vitro Thrombosis Test for Ventricular Assist Devices

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In Vitro Thrombosis Test for Ventricular Assist Devices.

Mansur Zhussupbekov1, Scott Stelick2, Rugveda Thanneeru3

  • 1Meinig School of Biomedical Engineering, Cornell University; mz332@cornell.edu.

Journal of Visualized Experiments : Jove
|April 7, 2025
PubMed
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This study presents a new in vitro method to assess ventricular assist device (VAD) thrombogenicity, identifying high-risk areas early in VAD development. The protocol aids in mitigating thrombosis risks before animal testing.

Area of Science:

  • Biomedical Engineering
  • Cardiovascular Devices
  • Thrombosis Research

Background:

  • Thrombosis is a major risk with ventricular assist devices (VADs).
  • Current animal study methods for VAD thrombogenicity are expensive, slow, ethically challenging, and may not predict human outcomes.
  • There is a need for more effective and accessible VAD thrombogenicity assessment.

Purpose of the Study:

  • To develop an aggressive in vitro testing protocol for VADs.
  • To identify potential thrombogenic hotspots in VADs.
  • To provide a practical tool for early-stage VAD development and risk mitigation.

Main Methods:

  • An aggressive in vitro protocol was developed to provoke thrombosis.
  • The protocol uses a modified anticoagulation strategy and accessible components.

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Last Updated: May 17, 2025

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  • Iterative testing and refinement were performed on a pediatric VAD (PediaFlow PF5).

    • Main Results:

    • The method successfully identified thrombogenic hotspots in VAD prototypes.
    • Design and manufacturing flaws leading to thrombosis were detected.
    • Targeted improvements were enabled before progression to animal studies.

    Conclusions:

    • The developed in vitro protocol is a practical tool for VAD thrombogenicity assessment.
    • It effectively identifies high-risk areas, aiding early design improvements.
    • This method complements existing approaches, enhancing VAD safety and development.