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Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices

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Parenteral drug delivery systems play a crucial role in modern therapeutics by enabling the direct administration of drugs into the systemic circulation, bypassing the gastrointestinal tract. These systems are particularly valuable for poorly absorbed oral medications that are unstable in the digestive environment or require rapid onset or sustained therapeutic levels. Delivery is achieved through intravenous, intramuscular, or subcutaneous routes, each selected based on the drug's properties...

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Related Experiment Video

Updated: Apr 29, 2026

Synthesis of Thermogelling PolyN-isopropylacrylamide-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering

Synthesis of Thermogelling PolyN-isopropylacrylamide-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering

Published on: October 26, 2016

Injectable Hydrogel Technologies for Bone Disease Treatment.

Ahmed M Salama¹, John G Hardy^2,3, Abdurohman Mengesha Yessuf⁴

¹State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing 100029, China.

ACS Applied Bio Materials

|April 7, 2025

Summary

This summary is machine-generated.

Injectable hydrogels offer localized drug delivery for bone diseases like osteoporosis. These smart materials show promise for targeted therapies but require further research for clinical use.

Keywords:

bone diseases hydrogels injectable point-of-care self-healing

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Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

Area of Science:

Biomaterials Science
Regenerative Medicine
Drug Delivery Systems

Background:

Injectable hydrogels are advanced biomaterials for localized drug delivery systems (DDSs).
They are suitable for managing bone disorders including osteoporosis, osteonecrosis, osteoarthritis, osteomyelitis, and osteosarcoma.
Hydrogels possess biocompatibility, tunable properties, and responsiveness to various stimuli for targeted delivery.

Purpose of the Study:

To review the synthesis and recent advancements of injectable hydrogels for bone disorder treatment.
To focus on their mechanisms as localized and sustained DDSs for diverse therapeutic agents.
To highlight clinical studies and future potential in bone disease therapy.

Main Methods:

Review of current literature on injectable hydrogel synthesis and applications in bone disease.
Analysis of hydrogel properties, stimuli-responsiveness, and drug delivery mechanisms.
Evaluation of clinical studies and point-of-care technologies.

Main Results:

Injectable hydrogels demonstrate significant potential for localized and sustained delivery of drugs, nanoparticles, growth factors, and cells.
Stimuli-responsive hydrogels enhance targeted delivery of bioactive agents for bone regeneration and disease management.
Clinical studies show promise, with potential synergy with point-of-care technologies.

Conclusions:

Injectable hydrogels can revolutionize bone disease treatment through precise, sustained, and minimally invasive delivery.
Further research is needed to address challenges in long-term biocompatibility, scalability, reproducibility, and release kinetics.
Overcoming these challenges will advance bone disease therapy, regenerative medicine, and personalized healthcare.