Homicidality in a woman with a 47,XXX karyotype

The 47,XXX karyotype is a rare sex chromosome anomaly. A female with this karyotype is called a triple X or superfemale. This karyotype is usually not associated with a characteristic mental or physical phenotype. A 19-year-old female who committed homicide and was found to have a 47,XXX karyotype is described, and the possible correlation between sex chromosome anomalies and psychopathology or criminality is discussed.