Related Experiment Video
Updated: May 15, 2025
06:07
Monitoring PD-1-Blocking Antibodies Bound to T Cells Derived from a Drop of Peripheral Blood
Published on: February 5, 2020
5.6K
Quality of Life of Cancer Patients in Routine Clinical Care Using the Example of Checkpoint Inhibition Therapy: A
Philipp Ivanyi1, Bernd Alt-Epping2, Lars Bullinger3
1Clinic for Haematology, Haemostaseology, Oncology and Stem Cell Transplantation, Interdisciplinary Working Group on Renal Cell Tumors IAGN-DKG, Claudia von Schelling-Comprehensive Cancer Center Hannover, Hannover Medical School, Hannover, Germany.
Oncology Research and Treatment
|April 7, 2025
Summary
Quality of life (QoL) is crucial in cancer care, especially with immune checkpoint inhibitors (CPIs). This study provides consensus recommendations for assessing and integrating QoL into clinical decisions for better patient outcomes.
Area of Science:
- Oncology
- Clinical Practice
- Patient-Reported Outcomes
Background:
- Immune checkpoint inhibitors (CPIs) have improved cancer patient prognoses, highlighting the importance of quality of life (QoL) as a treatment factor.
- Standardized tools are needed for collecting and utilizing QoL data in clinical settings.
- This study establishes an interdisciplinary consensus on QoL in standard clinical practice.
Purpose of the Study:
- To develop interdisciplinary consensus recommendations for assessing and utilizing quality of life (QoL) in cancer patients undergoing immune checkpoint inhibitor (CPI) therapy.
- To provide guidance on integrating QoL assessment into routine clinical decision-making.
- To address the need for reliable QoL data collection in the context of modern cancer treatments.
Main Methods:
- An interdisciplinary expert panel (n=12) participated in structured interviews.
- Ten theses on QoL in CPI therapy were drafted based on initial interviews.
- A multi-stage, anonymous, qualitative Delphi process was conducted from May to December 2022 to reach consensus.
Main Results:
- Five consensus recommendations were agreed upon, organized into three key areas.
- Quality of life (QoL) is recognized as a complex, dynamic factor extending beyond treatment side effects.
- Mindful patient communication is foundational for QoL assessment and management.
- Structured, regular, and individualized QoL documentation is recommended to inform treatment decisions.
Conclusions:
- Individual quality of life (QoL) assessment is recommended before and during cancer therapy.
- QoL is particularly relevant for long-term responders to CPI therapy and in the adjuvant setting.
- The Delphi-derived recommendations offer practical guidance for clinicians.
More Related Videos
Related Concept Videos
01:21Cancer Survival Analysis
308
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
308
01:27Tumor Immunotherapy
411
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
411
02:50Combination Therapies and Personalized Medicine
4.8K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.8K
02:49Cancer Therapies
7.5K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.5K
01:27Nursing Ethical Principles II
895
Ethical principles are essential in guiding nurses to fulfill their responsibilities, focusing on the quality of nursing care and decision-making. These principles, including autonomy, beneficence, non-maleficence, justice, and fidelity, shape the ethical framework within healthcare settings.
Consider the following scenario, which illustrates how these principles are applied in the care of Mr. John, a fifty-year-old teacher diagnosed with metastatic liver cancer.
Initially, Mr. John's...
Consider the following scenario, which illustrates how these principles are applied in the care of Mr. John, a fifty-year-old teacher diagnosed with metastatic liver cancer.
Initially, Mr. John's...
895
02:57Targeted Cancer Therapies
7.4K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.4K