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Unveiling EIF5A2: A multifaceted player in cellular regulation, tumorigenesis and drug resistance

Xifeng Xiong1, Yanli Du2, Peng Liu3

  • 1Guangzhou Institute of Traumatic Surgery, Guangzhou Red Cross Hospital of Jinan University, Guangzhou, 510220, Guangdong, China; Guangzhou Institute of Burn Clinical Medicine, Guangzhou Red Cross Hospital of Jinan University, Guangzhou, 510220, Guangdong, China.

European Journal of Pharmacology
|April 7, 2025
PubMed

Insights

The eukaryotic initiation factor 5A2 gene (EIF5A2) is crucial for cell functions and cancer development. Its overexpression drives tumorigenesis and drug resistance, highlighting its clinical significance.

Area of Science:

  • Molecular Biology
  • Genetics
  • Cancer Research

Background:

  • The eukaryotic initiation factor 5A2 gene (EIF5A2) is a conserved, multifunctional gene involved in critical cellular processes like translation and RNA binding.
  • EIF5A2 overexpression is common in various cancers, where it acts as an oncoprotein, promoting tumor growth.
  • This gene also plays a role in drug resistance by modulating specific molecular pathways.

Purpose of the Study:

  • To review the structure and functions of EIF5A2 in normal cellular contexts.
  • To elucidate the role of EIF5A2 in tumorigenesis and its mechanisms.
  • To explore the involvement of EIF5A2 in drug resistance.

Main Methods:

  • Literature review and synthesis of existing research on EIF5A2.
  • Analysis of EIF5A2's functions in normal cellular processes.
  • Investigation of EIF5A2's role in cancer development and progression.
  • Examination of molecular pathways regulated by EIF5A2 in tumorigenesis and drug resistance.

Main Results:

  • EIF5A2 is a key regulator of translation elongation, RNA binding, and post-translational modifications.
  • Overexpression of EIF5A2 is a frequent event in multiple cancers, correlating with its oncogenic function.
  • EIF5A2 contributes to cancer drug resistance through the modulation of various signaling pathways.

Conclusions:

  • EIF5A2's multifaceted roles in cellular processes and cancer make it a significant factor in tumorigenesis.
  • The mechanisms underlying EIF5A2's function in cancer and drug resistance warrant further in-depth investigation.
  • Understanding EIF5A2's biological roles offers potential for clinical applications in cancer therapy.
Keywords:
Drug resistanceEIF5A2HypusineSignaling pathwayTumorigenesis

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