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PAQR4: From spatial regulation of cell signaling to physiological homeostasis and diseases

Zi-Yan Jin1, Zhi-Qiang Ling2

  • 1Zhejiang Cancer Hospital, Hangzhou, Zhejiang 310022, China; Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang 310018, China; Postgraduate Training base Alliance of Wenzhou Medical University (Zhejiang Cancer Hospital), Hangzhou, Zhejiang 310022, China.

Biochimica Et Biophysica Acta. Reviews on Cancer
|April 7, 2025
PubMed

Insights

Progestin and adipoQ receptor family member 4 (PAQR4) is linked to cancer progression and metabolic diseases. This review explores PAQR4

Area of Science:

  • Molecular biology and oncology
  • Cellular and metabolic pathways

Background:

  • Progestin and adipoQ receptor family member 4 (PAQR4) is a seven-transmembrane protein.
  • PAQR4 is increasingly recognized for its role in tumor progression and chemotherapy resistance.
  • Its dysregulation is associated with various diseases, highlighting its potential as a biomarker.

Purpose of the Study:

  • To systematically review the subcellular localization and structural characteristics of PAQR4.
  • To elucidate the functions of PAQR4 in cancer, metabolic diseases, and fertility.
  • To provide insights for future research and translational applications of PAQR4.

Main Methods:

  • Systematic literature review.
  • Analysis of existing data on PAQR4's localization, structure, and function.
  • Integration of findings related to cancer, metabolism, and fertility.

Main Results:

  • PAQR4 influences sphingolipid and glycerol metabolism, affecting cellular ceramide homeostasis.
  • PAQR4 plays a role in adipose tissue remodeling.
  • Evidence suggests PAQR4's involvement in multiple tumor types and its impact on treatment outcomes.

Conclusions:

  • PAQR4 is a significant factor in cancer development, metabolic regulation, and potentially fertility.
  • Understanding PAQR4's structure and function is crucial for developing novel therapeutic strategies.
  • PAQR4 represents a promising target for future clinical applications in oncology and metabolic disorders.

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