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Severity Classification of Pediatric Spinal Cord Injuries Using Structural MRI Measures and Deep Learning: A

Zahra Sadeghi-Adl1,2, Sara Naghizadehkashani2, Devon Middleton2

  • 1From the Department of Electrical and Computer Engineering (Z.S.-A.), Temple University, Philadelphia, Pennsylvania zahra.sadeghiadl@jefferson.edu.

AJNR. American Journal of Neuroradiology
|April 7, 2025
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Summary

Deep learning accurately detects pediatric spinal cord injury (SCI) and its severity using MRI-based structural measurements. This advanced approach improves diagnostic accuracy for better patient care in pediatric SCI management.

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Area of Science:

  • Neurology
  • Medical Imaging
  • Artificial Intelligence

Background:

  • Pediatric spinal cord injury (SCI) diagnosis is challenging due to difficulties in clinical assessment.
  • Accurate evaluation of spinal cord structural changes is crucial for effective treatment planning.

Purpose of the Study:

  • To evaluate structural characteristics (cross-sectional area, AP width, RL width) in pediatric SCI patients.
  • To compare these measures between typically developing (TD) and SCI pediatric participants.
  • To employ deep learning for SCI detection and severity assessment.

Main Methods:

  • Sixty-one pediatric participants (20 SCI, 41 TD) underwent 3T MRI scans.
  • T2-weighted MRI scans were used to measure spinal cord dimensions (CSA, AP, RL widths) at all vertebral levels.
  • Deep convolutional neural networks (CNNs) were trained to classify participants and determine injury severity (AIS category).

Main Results:

  • Significant structural differences (p<0.05) in CSA, AP, and RL widths were observed between SCI and TD groups.
  • CNN models achieved 96.59% accuracy in distinguishing SCI from TD participants.
  • AIS category classification was achieved with 94.92% accuracy.

Conclusions:

  • Integrating structural imaging measures with deep learning effectively classifies pediatric SCI and assesses severity.
  • Deep learning models demonstrate superior diagnostic accuracy compared to traditional machine learning.
  • This approach holds potential for improving pediatric SCI patient care.