Related Experiment Video
Updated: May 15, 2025
Localization, Identification, and Excision of Murine Adipose Depots
Published on: December 4, 2014
Human Adipose Tissue Metabolism in Obesity.
Shuhao Lin1, Michael D Jensen1
1Endocrine Research Unit, Mayo Clinic, Rochester, MN, USA.
Adipose tissue, once viewed as simple fat storage, is now understood to be crucial for energy balance and metabolic health. Impaired insulin sensitivity in obesity leads to excess free fatty acids and metabolic dysfunction.
Area of Science:
- Endocrinology
- Metabolic Disease Research
- Adipose Tissue Biology
Background:
- Adipose tissue is now recognized for its critical roles in energy homeostasis and endocrinology.
- It plays a central role in the development of metabolic diseases.
- Lipid storage and lipolysis in adipose tissue are regulated by hormones like insulin.
Purpose of the Study:
- To review the structure and metabolism of adipose tissue.
- To discuss the contribution of adipose tissue to metabolic diseases.
- To examine the role of inflammation in adipose tissue insulin resistance.
Main Methods:
- In vivo measurement of adipose insulin sensitivity in humans.
- Utilizing isotopic fatty acid tracers and the insulin clamp technique.
- Calculating insulin concentration for 50% lipolysis suppression.
Main Results:
- Obesity is associated with impaired insulin action on adipose tissue lipolysis.
- This impairment leads to elevated circulating free fatty acids and metabolic dysfunction.
- The precise cause of this insulin resistance remains unclear.
Conclusions:
- Adipose tissue insulin resistance in obesity contributes to metabolic dysfunction.
- Chronic inflammation in adipose tissue was hypothesized to cause insulin resistance.
- Further investigation is needed to clarify the role of inflammation in adipose tissue insulin resistance.
More Related Videos
06:08Author Spotlight: Semi-Automated Isolation of the Stromal Vascular Fraction from Murine White Adipose Tissue Using a Tissue Dissociator
Published on: May 19, 2023
06:50Isolation of Adipogenic and Fibro-Inflammatory Stromal Cell Subpopulations from Murine Intra-Abdominal Adipose Depots
Published on: August 16, 2020
Related Concept Videos
01:24Obesity
01:02Hypodermis
01:24Overview of Lipid Metabolism
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...