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Published on: October 30, 2014
Directional Macrocycle Transport, Release, and Recapture Enabled by a Rotaxane Transporter
Sohom Kundu1,2, Shubhadip Mallick1, Jan Riebe1
1Faculty of Chemistry (Organic Chemistry) and Center for Nanointegration Duisburg-Essen (CENIDE), University of Duisburg-Essen, Universitätsstrasse 7, 45141, Essen, Germany.
Abstract:
A transporter for a directional macrocycle transport, release, and recapture was constructed. This was achieved using a rotaxane featuring a dibenzo-24-crown-8 macrocycle, dibenzylammonium (DBA)/methyl triazolium (MTA) stations on the thread and anthracene/triisopropylsilyl-acetylene stoppers, respectively. In the protonated rotaxane, the macrocycle primarily resides on the DBA station, followed by directional shuttling to the MTA station upon treatment with base. Addition of fluoride as an additional chemical input cleaves the triisopropylsilyl stopper, leading to release of the macrocycle and the half-thread into solution. The released macrocycle can be recaptured by protonation, and the mechanical bond can be reestablished via CuAAC click reaction, enabled by the terminal acetylene unit on the half-thread. This generates an elongated second-generation rotaxane transporter, which was used for a second cycle of directional macrocycle transport and release, proving the possibility of an iterative operation of the rotaxane-transporter in this molecular design.
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