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Cross-sectional associations between physical activity and sedentary time with cardiovascular health in children from

K M Sansum1,2, B Bond1, R M Pulsford3

  • 1Children's Health and Exercise Research Centre, Public Health and Sport Sciences, University of Exeter Medical School, University of Exeter, Exeter, UK.

Scientific Reports
|April 8, 2025
PubMed

Insights

Promoting moderate to vigorous physical activity (MVPA) and reducing sedentary time (ST) is crucial for children

Area of Science:

  • Pediatric cardiovascular health
  • Exercise science and public health

Background:

  • Childhood cardiovascular disease (CVD) risk factors are influenced by physical activity (PA) and sedentary time (ST).
  • Understanding the relationship between different intensities of PA, ST, and CVD risk in children is essential for preventative strategies.

Purpose of the Study:

  • To investigate the associations between light PA (LPA), moderate to vigorous PA (MVPA), and ST with vascular structure, function, and clustered CVD risk factors in children.
  • To utilize a compositional data analysis framework to examine these relationships.

Main Methods:

  • Cross-sectional study of 4277 children (aged 10.6 years) using accelerometers to measure LPA, MVPA, and ST.
  • Cardiovascular outcomes included flow-mediated dilation, distensibility coefficient, pulse wave velocity, and a clustered CVD risk score.
  • Multiple linear regression analyses were performed using a compositional framework, adjusting for covariates.

Main Results:

  • No significant associations were found between LPA, MVPA, or ST and vascular structure or function.
  • Higher MVPA was inversely associated with clustered CVD risk in both boys and girls.
  • Higher ST was positively associated with clustered CVD risk, particularly in girls.

Conclusions:

  • While PA and ST did not directly impact vascular outcomes in this cohort, MVPA and ST are associated with clustered CVD risk factors.
  • Interventions promoting MVPA and reducing ST are recommended to mitigate CVD risk in children.

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