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Prognostic value of pretreatment peripheral blood hemoglobin×lymphocyte/monocyte ratio in patients with

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  • 1Deparment of Oncology, Second Xiangya Hospital, Changsha 410011, China. crystal0817@126.com.

Zhong Nan Da Xue Xue Bao. Yi Xue Ban = Journal of Central South University. Medical Sciences
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Summary

The pretreatment hemoglobin×lymphocyte/monocyte ratio (HLMR) is a significant prognostic biomarker for nasopharyngeal carcinoma (NPC) patients. This ratio helps predict survival outcomes in patients undergoing radiotherapy.

Keywords:
clinicopathological featureshemoglobin×lymphocyte/monocyte rationasopharyngeal carcinomaprognosis biomarkersurvival rate

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Area of Science:

  • Oncology
  • Hematology
  • Biomarkers

Background:

  • Peripheral blood cell counts are established prognostic indicators in various cancers.
  • The predictive value of these counts, specifically the hemoglobin×lymphocyte/monocyte ratio (HLMR), in nasopharyngeal carcinoma (NPC) requires further investigation.

Purpose of the Study:

  • To evaluate the prognostic significance of the pretreatment hemoglobin×lymphocyte/monocyte ratio (HLMR) in patients with non-recurrent, non-metastatic nasopharyngeal carcinoma (NPC).
  • To assess HLMR's utility as a biomarker for predicting survival outcomes in NPC patients undergoing definitive radiotherapy.

Main Methods:

  • Retrospective analysis of clinical and follow-up data from 805 NPC patients treated with radiotherapy or chemoradiotherapy.
  • Calculation of pretreatment HLMR using hemoglobin, lymphocyte, and monocyte counts.
  • Utilized Receiver Operating Characteristic (ROC) curves to determine the optimal HLMR cut-off value (605.5) for predicting 5-year survival.
  • Employed Cox proportional hazards models to identify independent prognostic factors for overall survival (OS) and progression-free survival (PFS).
  • Constructed and validated a nomogram incorporating T stage, N stage, and HLMR to predict patient survival rates.

Main Results:

  • Multivariate analysis identified T stage, N stage, ECOG score, concurrent chemoradiotherapy, and HLMR as independent prognostic factors for OS.
  • The pretreatment HLMR was significantly associated with OS (HR=0.648, P=0.013).
  • A nomogram integrating T stage, N stage, and HLMR demonstrated good predictive accuracy for 3-, 5-, and 7-year OS (C-index=0.713) in both training and validation cohorts.

Conclusions:

  • Pretreatment HLMR is a valuable and promising prognostic biomarker for nasopharyngeal carcinoma (NPC) patients.
  • The developed nomogram provides a reliable tool for estimating survival rates in NPC patients.