Cutaneous Adverse Events Following COVID-19 Vaccination in Japan: A Questionnaire Survey

Area of Science:

• Dermatology
• Vaccinology
• Public Health

Background:

• The widespread administration of COVID-19 vaccines has led to increased attention on potential adverse events.
• Cutaneous manifestations following vaccination require systematic investigation to understand their clinical spectrum.

Purpose of the Study:

• To investigate the clinical spectrum and characteristics of cutaneous adverse events (AEs) occurring after COVID-19 vaccination in Japan.
• To provide data to aid dermatologists in recognizing and managing these vaccine-related skin conditions.

Main Methods:

• A nationwide survey of dermatology facilities in Japan was conducted.
• An initial questionnaire identified facilities reporting AEs, followed by a detailed survey for specific case information.

Main Results:

• Urticaria, delayed local reactions, erythema multiforme (EM), and alopecia were the most frequently reported cutaneous AEs.
• In a detailed analysis, EM, bullous pemphigoid, and alopecia were primary concerns.
• The mean latency to onset was 13.1 days, with a mean symptom duration of 74.2 days.

Conclusions:

• The study highlights a range of potential dermatological adverse events post-COVID-19 vaccination.
• While causality is not established, awareness and recognition by dermatologists are crucial for patient care.
• Further research may be needed to elucidate the relationship between COVID-19 vaccines and specific dermatoses.