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Magnetic Resonance Imaging

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Related Experiment Video

Updated: May 21, 2025

In Vivo Tracking of Edema Development and Microvascular Pathology in a Model of Experimental Cerebral Malaria Using Magnetic Resonance Imaging

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Imaging Intravoxel Vessel Size Distribution in the Brain Using Susceptibility Contrast Enhanced MRI.

Natenael B Semmineh¹, Indranil Guha¹, Deborah Healey¹

¹Department of Cancer Systems Imaging, Cancer Neuroscience Program, Neuroimaging Innovations to Transform Cancer Care (NeuroCare) Program, The University of Texas MD Anderson Cancer Center, Houston, TX, 77025, USA.

|April 8, 2025

Summary

A new MRI method non-invasively images vessel size distribution (VSD) and cerebral blood volume (CBV). This approach aids in assessing vascular remodelling in diseases like cancer and diabetes.

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Area of Science:

Biomedical Imaging
Neuroimaging
Vascular Biology

Background:

Vascular remodelling is a key factor in numerous diseases, including cancer, neurodegeneration, fibrosis, hypertension, and diabetes.
Accurate assessment of vascular changes is crucial for understanding disease progression and treatment efficacy.

Purpose of the Study:

To develop and validate a novel, non-invasive MRI approach for imaging intravoxel vessel size distribution (VSD).
To enable a more comprehensive and quantitative assessment of vascular remodelling in preclinical and clinical settings.

Main Methods:

Utilized high-resolution light-sheet fluorescence microscopy of rodent brain vasculature.
Simulated gradient echo sampling of free induction decay and spin echo (GESFIDE) MRI signals.
Trained a deep learning model to predict cerebral blood volume (CBV) and VSD from simulated GESFIDE signals.

Main Results:

Demonstrated a strong correlation (r = 0.96) between true and predicted CBV in ex vivo experiments.
Observed high similarity between true and predicted VSDs (mean Bhattacharya Coefficient = 0.92).
The deep learning model successfully predicted CBV and VSD from MRI signals.

Conclusions:

The developed susceptibility-contrast based MRI approach enables non-invasive intravoxel VSD imaging.
This technique offers a transformative tool for interrogating vascular remodelling in disease and in response to treatment.
Further in vivo validation could establish this as a valuable preclinical and clinical tool.