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Short-Term Relief with Upadacitinib: A Case Report of Palmoplantar Pustulosis in a Pediatric Patient

Qinchen Gu1,2, Chen Zhang3, Zhimin Lin4

  • 1The Second School of Clinical Medicine, Zhejiang Chinese Medical University, Zhejiang, 310014, People's Republic of China.

Clinical, Cosmetic and Investigational Dermatology
|April 8, 2025
PubMed

Insights

Palmoplantar pustulosis (PPP) is a chronic skin condition affecting hands and feet. Upadacitinib showed significant therapeutic response in a pediatric case, offering hope for difficult-to-treat childhood PPP.

Area of Science:

  • Dermatology
  • Pediatric dermatology
  • Immunology

Background:

  • Palmoplantar pustulosis (PPP) is a chronic inflammatory skin condition characterized by pustules, erythema, and scales on the palms and soles.
  • Current treatment options for pediatric PPP are limited, with insufficient data on newer targeted therapies like upadacitinib in younger children.

Observation:

  • A pediatric patient presented with severe, recurrent palmoplantar pustulosis significantly impacting daily activities.
  • The patient had not responded adequately to previous treatments.

Findings:

  • Upadacitinib treatment for two months resulted in a significant therapeutic response in the pediatric patient.
  • Clinical improvement included reduction in erythema, scales, and pustules.

Implications:

  • This case suggests upadacitinib may be an effective treatment option for severe pediatric palmoplantar pustulosis.
  • Further research is warranted to establish the safety and efficacy of upadacitinib in children under 12 with PPP.

Keywords:
childrenpalmoplantar pustulosistreatmentupadacitinib

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