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Updated: May 15, 2025

Optimized LC-MS/MS Method for the High-throughput Analysis of Clinical Samples of Ivacaftor, Its Major Metabolites, and Lumacaftor in Biological Fluids of Cystic Fibrosis Patients
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From Oral to Sublingual: A Redefined Avanafil Tablet with a Breakthrough in Bioavailability and First-Pass Metabolism

Turky Omar Asar1, Omar D Al-Hejaili2, Hossam S El-Sawy3,4

  • 1Department of Biology, College of Science and Arts at Alkamil, University of Jeddah, Jeddah, Saudi Arabia.

Drug Design, Development and Therapy
|April 8, 2025
PubMed
Summary

Avanafil (AVA) sublingual tablets, enhanced with hydroxypropyl-beta-cyclodextrin (HP-β-CD), significantly improve bioavailability and extend action for erectile dysfunction treatment. This novel formulation bypasses first-pass metabolism, offering greater plasma exposure and potential clinical benefits.

Keywords:
avanafilerectile dysfunctioninclusion complexpharmacokinetic studysublingual tablets

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