Effects of a Moisturizer Containing Colloidal Oatmeal and Filaggrin Technology on Staphylococcus Species In Vitro

The pathophysiology of atopic dermatitis (AD) is multifactorial, with genetic predisposition, environmental exposures, and dysbiosis of the skin microbiome all associated with disease activity. Colonization by Staphylococcus aureus (S. aureus) is specifically associated with AD, and modifying the skin microbiota through topical skincare products may play a role in AD management. A moisturizer containing colloidal oatmeal, a patented filaggrin technology, niacinamide, and tocopheryl acetate was assessed for its impact on the growth, biofilm formation, and bacterial mix adhesion of S. aureus and/or S. epidermidis on reconstructed human epidermis (RHE). Compared to control conditions, the bacterial growth and adhesion of S. aureus were decreased compared to S. epidermidis in the presence of the moisturizer. Additionally, the moisturizer did not significantly induce nor inhibit the formation of S. aureus biofilm relative to control. Overall, the moisturizer improved the growth ratio of Staphylococcus species, shifting the predominant species from pathogenic S. aureus to commensal S. epidermidis, which may be clinically beneficial in the management of AD. J Drugs Dermatol. 2025;24(4):416-418. doi:10.36849/JDD.8706 .