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Related Experiment Video

Updated: May 15, 2025

Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts

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Harnessing Human Holobiome and Meta-Multi-Omics Analyses for Medical Applications.

Muhammed Erkan Karabekmez^1,2

¹Department of Bioengineering, Istanbul Medeniyet University, Istanbul, Türkiye.

Omics : a Journal of Integrative Biology

|April 8, 2025

Summary

The meta-multi-omics era, using advanced sequencing, will reveal connections between the human holobiome and diverse diseases. This approach will advance systems medicine and enable personalized precision medicine interventions for better health outcomes.

Keywords:

human holobiome metagenomics multiomics precision and personalized medicine preventive medicine systems medicine

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A Clinical Metaproteomics Workflow Implemented within Galaxy Bioinformatics Platform to Analyze Host-Microbiome Interactions Underlying Human Disease

A Clinical Metaproteomics Workflow Implemented within Galaxy Bioinformatics Platform to Analyze Host-Microbiome Interactions Underlying Human Disease

Published on: January 10, 2025

Area of Science:

Microbiology
Genomics
Systems Medicine

Background:

Next-generation sequencing has transformed biological research, particularly metagenomics.
Microbiotas across the human body are linked to health and disease.
Advancements in metagenomics have spurred related multi-omics fields.

Purpose of the Study:

To introduce the concept of the meta-multi-omics era in human holobiome research.
To highlight the potential of meta-multi-omics for understanding health and disease.
To emphasize the role in developing precision medicine.

Main Methods:

Leveraging next-generation sequencing technologies.
Integrating data from metagenomics, metatranscriptomics, and metaproteomics.
Analyzing the human holobiome through a multi-omics approach.

Main Results:

Illuminating the complex relationships between the human holobiome and various health conditions.
Identifying key determinants of human health.
Providing a foundation for personalized medical strategies.

Conclusions:

The meta-multi-omics era is crucial for advancing systems medicine.
This approach will deepen our understanding of diseases ranging from cancer to psychiatric conditions.
It paves the way for tailored precision medicine interventions.