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lncRNA - Long Non-coding RNAs

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Updated: May 15, 2025

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The long noncoding RNA CCDC144NL-AS1: prognosis significance and potential biological functions in cervical

Xuemei Hu¹, Yulong Wang¹, Hongyu Guo¹

¹Department of Obstetrics and Gynecology, Lanzhou University Second Hospital, Lanzhou, China.

Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology

|April 8, 2025

Summary

This summary is machine-generated.

The long noncoding RNA CCDC144NL-AS1 is upregulated in cervical cancer (CC), promoting tumor cell migration and the epithelial-mesenchymal transition (EMT). This lncRNA serves as a potential prognostic biomarker and therapeutic target for CC.

Keywords:

CCDC144NL-AS1 cervical carcinoma long noncoding RNA prognosis

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Area of Science:

Oncology
Molecular Biology
RNA Biology

Background:

Long noncoding RNAs (lncRNAs) play regulatory roles in various cancers.
The specific role of lncRNA CCDC144NL-AS1 in cervical carcinoma (CC) pathogenesis is not well understood.

Purpose of the Study:

To investigate the expression and functional significance of lncRNA CCDC144NL-AS1 in cervical carcinoma.
To evaluate CCDC144NL-AS1 as a potential prognostic marker and therapeutic target for CC.

Main Methods:

Quantitative RT-PCR was used to measure CCDC144NL-AS1 expression in 86 CC samples and cell lines.
CC cell lines were engineered for CCDC144NL-AS1 overexpression to study its effects on cell migration and epithelial-mesenchymal transition (EMT).
Xenograft models were utilized to assess the in vivo impact of CCDC144NL-AS1 on tumor growth and survival.

Main Results:

CCDC144NL-AS1 expression was significantly elevated in CC tissues and cell lines compared to normal controls.
Increased CCDC144NL-AS1 expression correlated with advanced clinical stage, higher histologic grade, and lymph node metastasis.
Higher CCDC144NL-AS1 levels were associated with poorer patient survival and promoted cell viability, migration, and EMT.
In vivo studies showed that reduced CCDC144NL-AS1 levels led to smaller tumors and improved survival.

Conclusions:

CCDC144NL-AS1 is significantly upregulated in cervical cancer and promotes tumor progression by enhancing cell migration and EMT.
CCDC144NL-AS1 demonstrates potential as a valuable prognostic indicator and a promising therapeutic target for cervical carcinoma.