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Detailed Comprehensive Review on Advancement of Cubosomes and their Currently Available Applications
Raghwendra R Waghmode1, Pranay Wal2, Seshadri Nalla3
1Krishna Institute of Pharmacy, Krishna Vishwa Vidyapeeth (Deemed To Be University), Karad-415539, Maharashtra, India.
Current Pharmaceutical Biotechnology
|April 8, 2025
Summary
Cubosomes, a novel lipid-based nanotechnology, offer stable, targeted drug delivery for various therapies. Further research is needed to overcome challenges for widespread clinical use.
Area of Science:
- Nanotechnology
- Materials Science
- Pharmaceutics
Background:
- Cubosomes are nanostructured lipid carriers with unique structures integrating amphiphilic lipids and polymer stabilizers.
- They offer potential in drug delivery due to bioadhesive properties, thermodynamic stability, and encapsulation capabilities.
Purpose of the Study:
- To review the scientific principles, structure, composition, and processing of cubosomes for drug delivery.
- To explore their therapeutic applications, distribution pathways, and challenges hindering clinical use.
Main Methods:
- Bibliographic review of major electronic databases and academic libraries.
- Analysis of cubosome composition, digestion principles, processing, and administration routes.
Main Results:
- Cubosomes, typically composed of glyceryl monooleate and Phytantriol with a stabilizer, enable sustained and targeted drug release.
- Potential applications include cancer, antimicrobial, vaccine, ocular, dermatological, and transdermal delivery.
Conclusions:
- Cubosomes represent a versatile nanotechnology for targeted drug delivery with broad application potential.
- Addressing current limitations is crucial for advancing their clinical application.
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