Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Tissue Transplantation01:24

Tissue Transplantation

283
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
283

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Multi-ancestry modeling improves fine-mapping resolution, protein prediction, and discovery for proteome-wide association studies.

medRxiv : the preprint server for health sciences·2026
Same author

Correction to: Retromuscular prophylactic mesh reinforcement after midline laparotomy: a systematic review and meta-analysis.

Hernia : the journal of hernias and abdominal wall surgery·2026
Same author

Association between metabolic obesity phenotypes and erectile dysfunction: Insights from a nationally cross-sectional study.

Medicine·2026
Same author

Relationship between MLH1, MSH2, MSH6, and PMS2 protein expression status and clinicopathological characteristics in colorectal cancer tissues.

Frontiers in medicine·2026
Same author

Germinal Center-Like Tertiary Lymphoid Structures Mark Immune Responsiveness and Enable Checkpoint Immunotherapy in Bladder Cancer.

Oncology research·2026
Same author

A NEK2/ZWINT-NDC80 regulatory axis drives bladder cancer progression and chemoresistance.

Discover oncology·2026

Related Experiment Video

Updated: May 15, 2025

Quantification of Circulating Pig-Specific DNA in the Blood of a Xenotransplantation Model
07:34

Quantification of Circulating Pig-Specific DNA in the Blood of a Xenotransplantation Model

Published on: September 22, 2020

3.9K

The International Human Xenotransplantation Inventory: Current Data and Future Directions.

Xiaowei Hu1,2, Wayne J Hawthorne3, Leo Buhler2

  • 1Division of Anaesthesiology, Department of Acute Care Medicine, Geneva University Hospitals, Geneva, Switzerland.

Transplantation
|April 8, 2025
PubMed
Summary

Xenotransplantation offers a solution to organ shortages. A global registry tracks human xenotransplantation practices, revealing trends and supporting future advancements in animal-to-human transplants.

More Related Videos

Xenograft Skin Model to Manipulate Human Immune Responses In Vivo
08:23

Xenograft Skin Model to Manipulate Human Immune Responses In Vivo

Published on: June 29, 2022

2.8K
Induction and Scoring of Graft-Versus-Host Disease in a Xenogeneic Murine Model and Quantification of Human T Cells in Mouse Tissues using Digital PCR
06:06

Induction and Scoring of Graft-Versus-Host Disease in a Xenogeneic Murine Model and Quantification of Human T Cells in Mouse Tissues using Digital PCR

Published on: May 23, 2019

7.0K

Related Experiment Videos

Last Updated: May 15, 2025

Quantification of Circulating Pig-Specific DNA in the Blood of a Xenotransplantation Model
07:34

Quantification of Circulating Pig-Specific DNA in the Blood of a Xenotransplantation Model

Published on: September 22, 2020

3.9K
Xenograft Skin Model to Manipulate Human Immune Responses In Vivo
08:23

Xenograft Skin Model to Manipulate Human Immune Responses In Vivo

Published on: June 29, 2022

2.8K
Induction and Scoring of Graft-Versus-Host Disease in a Xenogeneic Murine Model and Quantification of Human T Cells in Mouse Tissues using Digital PCR
06:06

Induction and Scoring of Graft-Versus-Host Disease in a Xenogeneic Murine Model and Quantification of Human T Cells in Mouse Tissues using Digital PCR

Published on: May 23, 2019

7.0K

Area of Science:

  • Medical Science
  • Transplantation Biology
  • Bioethics

Background:

  • Global organ demand exceeds supply, creating a critical need for alternative solutions.
  • Xenotransplantation, utilizing animal organs, cells, and tissues, is a promising approach to address this shortage.
  • Transparency and best practices in transplantation are emphasized by organizations like the World Health Organization.

Purpose of the Study:

  • To present the establishment and evolution of an online inventory cataloging human xenotransplantation practices.
  • To analyze trends in xenotransplantation over the past two decades based on registry data.
  • To highlight the significance of xenotransplantation research and regulatory changes in recent clinical advancements.

Main Methods:

  • Collaborative establishment of an online inventory by the World Health Organization and the International Xenotransplantation Association in 2006.
  • Systematic data collection from diverse sources including publications, congresses, and press articles.
  • Rigorous verification and regular updates of xenotransplantation entries by dedicated teams in Switzerland and China.

Main Results:

  • As of May 2024, the inventory documented 54 distinct human xenotransplantation procedures.
  • Analysis revealed observable trends in transplantation types, regulatory status, and source animals over two decades.
  • Recent high-profile solid organ xenotransplant cases underscore the progress driven by research and regulatory evolution.

Conclusions:

  • Recent clinical successes in solid organ xenotransplantation indicate a potential increase in procedures for conditions like kidney failure, heart disease, and diabetes.
  • The findings support the expansion of the current registry or its integration into a larger international platform.
  • Increased funding and broader international recognition are crucial for advancing xenotransplantation research and application.