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Genetic Biomarkers for Periodontal Diseases: A Systematic Review
H Dommisch1, D Hoedke1, E M-C Lu2
1Department of Periodontology, Oral Medicine and Oral Surgery, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Berlin, Germany.
Journal of Clinical Periodontology
|April 8, 2025
Summary
No genetic biomarkers currently offer clinical value for diagnosing or managing periodontal disease. Future research may explore polygenic risk scores and single-marker tests for specific forms of the disease.
Area of Science:
- Genetics
- Periodontology
- Biomarker Discovery
Background:
- Periodontal diseases, including gingivitis and periodontitis, represent a significant global health burden.
- Genetic factors are implicated in the susceptibility and progression of periodontal diseases.
- The identification of reliable genetic biomarkers is crucial for improved diagnosis, prevention, and management.
Conclusions:
- Currently, no genetic diagnostic test possesses sufficient clinical value for periodontal disease diagnosis, prevention, or prediction of treatment outcomes.
- Future research directions include exploring polygenic risk scores for susceptibility and single-marker testing for monogenic/oligogenic forms of periodontal disease.
